INT225778

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
chondrocyte 2
Igf1 (Mus musculus)
Ppi-rs (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 15 93.68 High High
cytokine 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 13 94.08 High High
Osteoarthritis 15 93.68 High High
Calcification 46 93.44 High High
Metabolic Disorder 1 90.00 High High
Chondrocalcinosis 3 84.04 Quite High
Disease 8 49.40 Quite Low
Osteoporosis 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression and responsiveness, which drives PPi generation and release mediated via NPP1 and ANK, and diminished responsiveness to IGF-I, which normally suppresses elevation of chondrocyte extracellular PPi.
IGF-I Negative_regulation (suppresses) of Positive_regulation (elevation) of PPi in chondrocyte
1) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.82 Pain Relevance 0.14

General Comments

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