INT22578

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Context Info
Confidence 0.77
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 43
Total Number 44
Disease Relevance 11.02
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
neuronal 6
nucleus 3
ileum 1
neurons 1
caudate putamen 1
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 340 98.64 Very High Very High Very High
Migraine 4 97.88 Very High Very High Very High
Nucleus accumbens 2 94.08 High High
cytokine 207 93.88 High High
Sciatic nerve 29 93.20 High High
Spinal cord 8 92.64 High High
Neurotransmitter 100 92.16 High High
alcohol 4 92.00 High High
Inflammation 369 88.56 High High
Inflammatory response 46 87.32 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.84 Very High Very High Very High
Atherosclerosis 6 99.84 Very High Very High Very High
Diabetes Mellitus 102 99.80 Very High Very High Very High
Periodontitis 90 99.68 Very High Very High Very High
Fibrosarcoma 40 99.44 Very High Very High Very High
Brain Injury 146 98.16 Very High Very High Very High
Headache 4 97.88 Very High Very High Very High
Targeted Disruption 59 96.40 Very High Very High Very High
Cancer 61 95.84 Very High Very High Very High
Necrosis 25 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of p65 in ganglion explants increased by 40-100% when the cultures were treated with the depolarizing agents, veratridine or high potassium.
Gene_expression (expression) of p65 in ganglion associated with ganglion cysts
1) Confidence 0.77 Published 1990 Journal J. Neurobiol. Section Abstract Doc Link 2307976 Disease Relevance 0.10 Pain Relevance 0.12
Taken together, these results indicate that Akt downregulates the expression of MafK, SytI, and Syn-1.
Gene_expression (expression) of SytI
2) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.11 Pain Relevance 0.18
Effect of an Akt-specific inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (WT-Akt) cells
Gene_expression (expression) of SytI
3) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0
In the present study, we demonstrate that Akt downregulates the expression of several genes of neuronal functions, including MafK, SytI, and Syn-1, and some other genes such as Canx and Cadm1 (Table 2).
Gene_expression (expression) of SytI in neuronal
4) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.27 Pain Relevance 0
pathway does not appear to be implicated in the decreased expression of SytI in PC12 (WT-Akt).
Gene_expression (expression) of SytI
5) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
Therefore, it can be suggested that decreased expression of SytI in PC12 (WT-Akt) cells might be due to the Akt-mediated inhibition of the Raf-MAPK pathway.
Gene_expression (expression) of SytI
6) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
The infarct size, expression of NF-kappaB subunit p65 mRNA and protein and intercellular adhesion molecule-1 mRNA were examined.
Gene_expression (expression) of p65
7) Confidence 0.58 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19829116 Disease Relevance 0.08 Pain Relevance 0
Expression of SytI in sympathetic neurons has been shown to be induced by BMP4 [27], and BMP4 signaling is known to be mediated by Smad proteins and MAPKs [57,58].
Gene_expression (Expression) of SytI in neurons
8) Confidence 0.52 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
Approximately seventy genes including v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (MafK), synaptotagmin I (SytI), and syntenin-1 (Syn-1) were recognized as genes expressed at a higher level in cells that express have PC12 (DN-Akt) cells.
Gene_expression (expressed) of synaptotagmin I associated with fibrosarcoma
9) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.38 Pain Relevance 0.04
Approximately seventy genes including v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (MafK), synaptotagmin I (SytI), and syntenin-1 (Syn-1) were recognized as genes expressed at a higher level in cells that express have PC12 (DN-Akt) cells.
Gene_expression (express) of SytI associated with fibrosarcoma
10) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.38 Pain Relevance 0.04
This could be Brn3, because this is the only transcription factor identified so far that could increase the expression of SytI in neuronal cells [59], and interestingly it has the preferred phosphorylation motif of Akt [31].


Gene_expression (expression) of SytI in neuronal
11) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.03
Approximately seventy genes including v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (MafK), synaptotagmin I (SytI), and syntenin-1 (Syn-1) were recognized as genes expressed at a higher level in cells that express have PC12 (DN-Akt) cells.
Gene_expression (expressed) of SytI associated with fibrosarcoma
12) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.38 Pain Relevance 0.04
Using PC12 cells expressing wild-type or dominant-negative Akt and also using a pharmacological inhibitor of Akt, we demonstrate that Akt can negatively affect the expression of MafK, SytI, and Syn-1 genes.
Gene_expression (expression) of SytI
13) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.05
These data, together, indicate that Akt downregulates the levels of MafK, SytI, and Syn-1 transcripts.
Gene_expression (levels) of SytI
14) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.07
In summary, Akt regulates the expression of MafK, SytI, and Syn-1, which are all neuronal function-related genes.


Gene_expression (expression) of SytI in neuronal
15) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.05
We then measured the transcript levels of MafK, SytI, and Syn-1 using semi-quantitative PCR.
Gene_expression (levels) of SytI
16) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.09
These results indicate that dominant-negative or pharmacological inhibition of Akt increases the expression of MafK, SytI, and Syn-1 genes.
Gene_expression (expression) of SytI
17) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2844376 Disease Relevance 0.24 Pain Relevance 0.04
Taken together, these results indicate that Akt negatively regulates the expression of MafK, SytI, and Syn-1 genes that all participate in regulating neuronal integrity in some way or another.



Gene_expression (expression) of SytI in neuronal
18) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2844376 Disease Relevance 0.22 Pain Relevance 0.03
inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (DN-Akt) cells
Gene_expression (expression) of SytI
19) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function

Background

Gene_expression (expression) of synaptotagmin I in neuronal
20) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2844376 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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