INT225787

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.44
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ank) plasma membrane (Ank)
Ppi-rs (Mus musculus)
Ank (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 15 100.00 Very High Very High Very High
cytokine 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 15 100.00 Very High Very High Very High
Chondrocalcinosis 3 99.48 Very High Very High Very High
Metabolic Disorder 1 93.60 High High
Calcification 46 85.64 High High
Aging 13 78.92 Quite High
Disease 8 71.56 Quite High
Osteoporosis 4 9.96 Low Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, excess extracellular PPi also may result from heightened release of intracellular PPi via increased ANK expression in OA and abnormal ANK function in familial chondrocalcinosis, as well as from deficient activity of pyrophosphatases (such as TNAP and possibly inorganic pyrophosphatase) in certain primary metabolic disorders.
PPi Spec (may) Positive_regulation (result) of Gene_expression (function) of ANK associated with chondrocalcinosis, metabolic disorder and osteoarthritis
1) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.44 Pain Relevance 0.19

General Comments

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