INT22579

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Context Info
Confidence 0.65
First Reported 1984
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 2.77
Pain Relevance 16.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pancreas 2
mast cell 2
neuronal 1
smooth muscle 1
endothelium 1
Efs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 29 100.00 Very High Very High Very High
Nicotine 20 100.00 Very High Very High Very High
substance P 21 99.94 Very High Very High Very High
Morphine 47 99.92 Very High Very High Very High
dexamethasone 20 99.92 Very High Very High Very High
Enkephalin 12 99.90 Very High Very High Very High
tetrodotoxin 38 99.72 Very High Very High Very High
antagonist 16 99.32 Very High Very High Very High
narcan 33 99.24 Very High Very High Very High
agonist 29 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 24 98.48 Very High Very High Very High
Hypertension 9 97.56 Very High Very High Very High
Sprains And Strains 4 94.60 High High
Overactive Bladder 28 82.96 Quite High
Increased Venous Pressure Under Development 2 80.80 Quite High
Targeted Disruption 2 75.00 Quite High
INFLAMMATION 1 75.00 Quite High
Pressure And Volume Under Development 1 64.32 Quite High
Stress 1 25.00 Low Low
Sleep Disorders 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In separate series of experiments, EFS was repeated in the presence of ketamine, propofol, and midazolam at concentrations of 10?
Localization (repeated) of EFS associated with versed and ketamine
1) Confidence 0.65 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2978435 Disease Relevance 0.16 Pain Relevance 0.16
Goblet cells in colonic crypts, but not those on the mucosal surface, secreted mucus in response to EFS.
Localization (secreted) of EFS in Goblet cells
2) Confidence 0.61 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6507624 Disease Relevance 0 Pain Relevance 0.25
Furthermore, following preincubation with either TTX or atropine, EFS' failed to elicit secretion.
Localization (secretion) of EFS associated with tetrodotoxin
3) Confidence 0.61 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6507624 Disease Relevance 0 Pain Relevance 0.39
Bombesin and substance P were released during prolonged EFS.
Localization (released) of EFS associated with substance p
4) Confidence 0.61 Published 1989 Journal Gastroenterology Section Abstract Doc Link 2463203 Disease Relevance 0 Pain Relevance 0.30
Atropine (10(-6) M) or indomethacin (10(-5) M) also attenuated SP + EFS-induced mast cell secretion.
Localization (secretion) of EFS in mast cell associated with substance p
5) Confidence 0.60 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8764224 Disease Relevance 0 Pain Relevance 0.68
SP + EFS-induced mast cell secretion was significantly attenuated by 10(-6) M tetrodotoxin.
Localization (secretion) of EFS in mast cell associated with tetrodotoxin and substance p
6) Confidence 0.60 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8764224 Disease Relevance 0 Pain Relevance 0.68
These results suggest that EFS of SHR mesenteric arteries releases neurogenic NO, the metabolism of which is increased in the presence of ET-1 by the generation of superoxide anions.
Localization (releases) of EFS
7) Confidence 0.52 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11065212 Disease Relevance 0.07 Pain Relevance 0.25
The EFS-evoked [3H]-noradrenaline (NA) release was significantly greater in TGR than in SD rats.
Localization (release) of EFS associated with noradrenaline
8) Confidence 0.49 Published 1996 Journal J Auton Pharmacol Section Abstract Doc Link 8842867 Disease Relevance 0.70 Pain Relevance 0.31
An anti-GRP antiserum inhibited the EFS-enhanced secretin-induced secretions of fluid and amylase by 12 and 43%, respectively, whereas a simultaneous infusion of the antiserum and atropine completely abolished them.
Localization (secretions) of EFS
9) Confidence 0.46 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10762609 Disease Relevance 0 Pain Relevance 0.10
The EFS-evoked INS and GLU secretion is probably executed via different mechanisms.
Localization (secretion) of EFS
10) Confidence 0.45 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11440274 Disease Relevance 0.53 Pain Relevance 0.44
In the present study we investigated the effects of dexamethasone on EFS (electrical field stimulation)-induced NO release in MAs from WKY (Wistar-Kyoto) rats and SHRs (spontaneously hypertensive rats) and the role of PKC (protein kinase C) in this response.
Neg (NO) Localization (release) of EFS associated with kinase c, hypertension and dexamethasone
11) Confidence 0.41 Published 2009 Journal Clin. Sci. Section Abstract Doc Link 19267693 Disease Relevance 0.17 Pain Relevance 0.41
In SHR MAs, dexamethasone decreased basal and EFS-induced neuronal NO release, and this decrease was prevented by the glucocorticoid receptor antagonist mifepristone.
Neg (NO) Localization (release) of EFS in neuronal associated with antagonist and dexamethasone
12) Confidence 0.41 Published 2009 Journal Clin. Sci. Section Abstract Doc Link 19267693 Disease Relevance 0.24 Pain Relevance 0.62
Atropine (10(-5) M) did not inhibit the EFS (5 Hz)-evoked INS secretion in normal pancreas and failed to alter the effect of EFS (10-20 Hz) on INS secretion from the pancreas of both normal and diabetic rats.
Localization (secretion) of EFS in pancreas associated with diabetes mellitus
13) Confidence 0.40 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11440274 Disease Relevance 0.41 Pain Relevance 0.30
Atropine (10(-5) M) did not inhibit the EFS (5 Hz)-evoked INS secretion in normal pancreas and failed to alter the effect of EFS (10-20 Hz) on INS secretion from the pancreas of both normal and diabetic rats.
Localization (secretion) of EFS in pancreas associated with diabetes mellitus
14) Confidence 0.40 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11440274 Disease Relevance 0.41 Pain Relevance 0.27
The modulatory effects of agonists and antagonists of prejunctional alpha2-adrenoceptors on the electrical field stimulation (EFS, 0.3 ms, 12 V)-induced release of endogenous noradrenaline (NA) and the cotransmitter adenosine 5' triphosphate (ATP) were measured in endothelium-denuded segments of canine inferior mesenteric artery and compared with effects in mesenteric vein.
Localization (release) of EFS in endothelium associated with adenocard, antagonist, noradrenaline and agonist
15) Confidence 0.17 Published 2001 Journal J Auton Pharmacol Section Abstract Doc Link 11422578 Disease Relevance 0 Pain Relevance 0.50
In contrast to the smooth muscle response, however, EFS-induced release of prostanoids was not significantly altered in the presence of TTX.
Localization (release) of EFS in smooth muscle associated with tetrodotoxin
16) Confidence 0.09 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932167 Disease Relevance 0.07 Pain Relevance 0.40
Diltiazem abolished the nicotine-induced ACh release completely but did not affect the EFS-induced release and significantly increased the high-K(+)-induced ACh release.
Localization (release) of EFS associated with nicotine
17) Confidence 0.05 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2308231 Disease Relevance 0 Pain Relevance 0.31
Verapamil inhibited the nicotine-induced ACh release remarkably and the EFS- or the high-K(+)-induced ACh release to a lesser extent.
Localization (release) of EFS associated with nicotine
18) Confidence 0.05 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2308231 Disease Relevance 0 Pain Relevance 0.31
In the present study, we investigated the effects of various Ca2+ blockers on the release of acetylcholine (ACh) induced by nicotine, electrical field stimulation (EFS) and high-K+.
Spec (investigated) Localization (release) of EFS associated with nicotine
19) Confidence 0.05 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2308231 Disease Relevance 0 Pain Relevance 0.25
Since the nicotine- and the EFS-induced ACh releases were inhibited by procaine, the local anesthetic property of verapamil likely contributes in part to the inhibition.
Localization (releases) of EFS associated with nicotine and local anesthetic
20) Confidence 0.05 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2308231 Disease Relevance 0 Pain Relevance 0.32

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