INT225802

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
osteoblasts 1
Enpp1 (Mus musculus)
Ppi-rs (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 30 64.44 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calcification 92 100.00 Very High Very High Very High
Metastasis 2 91.12 High High
Obesity 2 88.96 High High
Adhesions 2 87.72 High High
Insulin Resistance 2 80.20 Quite High
Diabetes Mellitus 4 72.56 Quite High
Osteoporosis 8 69.20 Quite High
Osteoarthritis 30 64.44 Quite High
Disease 16 48.52 Quite Low
Cleidocranial Dysplasia 2 48.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Last, NPP1 not only generates PPi but also modulates N-glycosylation and secretion of glycoproteins, and proteoglycans sulfation [6–8], and NPP1 also scavenges ATP and thereby regulates purinergic receptor signaling.
NPP1 Binding (generates) of PPi
1) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0.03
This review focuses on the functions of NPP1 in the regulation of physiologic and pathologic calcification, principally via PPi generation from nucleoside triphosphates in tissues (and cells) including cartilage (and chondrocytes), bone (and osteoblasts), and large arteries (and smooth muscle cells (SMCs)).


NPP1 Binding (generation) of PPi in osteoblasts associated with calcification
2) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0

General Comments

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