INT225805

Context Info Confidence 0.42 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.43 Pain Relevance 0.09

nucleoplasm (SNRNP70) generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) mRNA processing (SNRNP70) RNA binding (SNRNP70) plasma membrane (Enpp1)

SNRNP70 (Homo sapiens) Enpp1 (Mus musculus) SNRNP70 - K173Q (2)

Pain Link Frequency Relevance Heat Osteoarthritis 30 88.76 cytokine 6 5.00 depression 4 5.00 Inflammation 4 5.00 adenocard 4 5.00 spinal inflammation 2 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 2 100.00 Diabetes Mellitus 4 96.88 Obesity 2 90.88 Osteoarthritis 30 88.76 Calcification 92 75.88 Disease 16 72.84 Cleidocranial Dysplasia 2 72.40 Aging 26 43.52 Renal Insufficiency 2 29.08 Increased Venous Pressure Under Development 2 24.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, the K173Q SNP of NPP1, which maps to the second somatomedin-B-like domain of NPP1 and has been linked to insulin resistance, does not modulate NPP1 dimerization or catalytic activity or affect physical interaction of NPP1 with the insulin receptor [68].

SNP (K173Q) Binding (interaction) of NPP1 associated with insulin resistance

1) Confidence 0.42 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.72 Pain Relevance 0.04

Interestingly, the K173Q SNP of NPP1, which maps to the second somatomedin-B-like domain of NPP1 and has been linked to insulin resistance, does not modulate NPP1 dimerization or catalytic activity or affect physical interaction of NPP1 with the insulin receptor [68].

SNP (K173Q) Binding (dimerization) of NPP1 associated with insulin resistance

2) Confidence 0.42 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.71 Pain Relevance 0.04

General Comments

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