INT225808

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1)
mRNA processing (SNRNP70) RNA binding (SNRNP70) plasma membrane (Enpp1)
SNRNP70 (Homo sapiens)
Enpp1 (Mus musculus)
SNRNP70 - K173Q (1)
Pain Link Frequency Relevance Heat
Osteoarthritis 15 88.76 High High
cytokine 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 1 100.00 Very High Very High Very High
Diabetes Mellitus 2 96.88 Very High Very High Very High
Osteoarthritis 15 88.76 High High
Obesity 1 84.96 Quite High
Calcification 46 75.88 Quite High
Disease 8 72.84 Quite High
Cleidocranial Dysplasia 1 72.40 Quite High
Aging 13 43.52 Quite Low
Renal Insufficiency 1 29.08 Quite Low
Increased Venous Pressure Under Development 1 24.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the K173Q SNP of NPP1, which maps to the second somatomedin-B-like domain of NPP1 and has been linked to insulin resistance, does not modulate NPP1 dimerization or catalytic activity or affect physical interaction of NPP1 with the insulin receptor [68].
SNP (K173Q) Neg (not) Regulation (modulate) of NPP1 associated with insulin resistance
1) Confidence 0.30 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.71 Pain Relevance 0.04

General Comments

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