INT22592

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.27
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hmbs) cytoplasm (Hmbs)
Anatomy Link Frequency
liver 1
Hmbs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 9 99.52 Very High Very High Very High
antagonist 1 99.10 Very High Very High Very High
Serotonin 2 98.72 Very High Very High Very High
anesthesia 2 90.00 High High
peripheral neuropathy 2 84.52 Quite High
Sciatic nerve 1 81.68 Quite High
Peripheral nervous system 1 79.28 Quite High
Dismenorea 1 71.12 Quite High
Disease Link Frequency Relevance Heat
Porphyria 13 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 8 98.00 Very High Very High Very High
Congenital Anomalies 2 92.16 High High
Acute Intermittent Porphyria 3 89.92 High High
Variegate Porphyria 1 86.80 High High
Peripheral Neuropathy 2 84.52 Quite High
Dysmenorrhea 1 71.12 Quite High
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SAD rats anesthetized with methohexital, PBG produced dose-dependent decreases in BP and RNA, whereas NIC produced dose-dependent increases in BP and decreases in RNA; the serotonin (5-HT3) antagonist MDL 72222 (80 micrograms ipc) abolished the responses to PBG but not to NIC.
Positive_regulation (responses) of PBG associated with pressure volume 2 under development, porphyria, antagonist, nicotine and serotonin
1) Confidence 0.48 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2309912 Disease Relevance 1.57 Pain Relevance 0.64
In the analysis of the enzymatic activities of the liver and bone narrow, the activity of ALA synthetase (ALA-S) was markedly increased, and the activities of both uroporphyrinogen I synthetase (URO-S) and ferrochelatase were decreased.
Positive_regulation (increased) of uroporphyrinogen I synthetase in liver
2) Confidence 0.10 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.70 Pain Relevance 0.23

General Comments

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