INT225958

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT12)
Anatomy Link Frequency
corneal epithelium 4
eye 2
RCE 1
conjunctiva 1
epithelial cells 1
KRT12 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 40 5.00 Very Low Very Low Very Low
medulla 28 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
cryotherapy 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 90.48 High High
Ichthyosis 4 88.84 High High
Targeted Disruption 81 78.40 Quite High
Astigmatism 2 65.08 Quite High
Conjunctiva Disease 15 59.00 Quite High
Syndrome 25 58.68 Quite High
Cancer 340 48.48 Quite Low
Epidermolytic Palmoplantar Keratoderma 4 24.84 Low Low
Injury 72 10.16 Low Low
Adenocarcinoma 184 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that the clinical severity observed in our pedigree is due to the structural change of the keratin 12 protein caused by the replacement of arginine with a proline residue, which is particularly incompatible with an ?
Gene_expression (change) of keratin 12 protein
1) Confidence 0.68 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774455 Disease Relevance 0.21 Pain Relevance 0
These keratins are expressed in all corneal epithelial cell layers, whereas in the limbus corneae only suprabasal cells are positive and the basally located corneal stem cells are K3/K12 negative (Schermer et al. 1986; Pitz and Moll 2002).
Gene_expression (expressed) of K12 in stem cells
2) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.24 Pain Relevance 0
K3/K12: keratins of the corneal epithelium
Gene_expression (keratins) of K12 in corneal epithelium
3) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
K3/K12: keratins of the corneal epithelium
Gene_expression (/) of K12 in corneal epithelium
4) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
These keratins are expressed in all corneal epithelial cell layers, whereas in the limbus corneae only suprabasal cells are positive and the basally located corneal stem cells are K3/K12 negative (Schermer et al. 1986; Pitz and Moll 2002).
Gene_expression (positive) of K12 in corneal epithelial cell
5) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
This is indirect evidence that EpiASC can survive in the host tissue and can be induced into corneal epithelium in vivo, which expresses CK3, CK12, and PAX-6.
Gene_expression (expresses) of CK12 in corneal epithelium
6) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426721 Disease Relevance 0 Pain Relevance 0
The reconstructed corneal epithelium (RCE) expressed CK3, CK12, and PAX-6 and had the function of secreting glycocalyx-like material (AB-PAS positive).
Gene_expression (expressed) of CK12 in RCE
7) Confidence 0.58 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2426721 Disease Relevance 0.10 Pain Relevance 0
The reconstructed corneal epithelium expressed CK3, CK12, and PAX-6 and had the function of secreting glycocalyx-like material (AB-PAS positive).
Gene_expression (expressed) of CK12 in corneal epithelium
8) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426721 Disease Relevance 0.25 Pain Relevance 0
The cultured oral cells do not express cytokeratin K12 or the eye-specific transcription factor, Pax-6.
Neg (not) Gene_expression (express) of K12 in eye
9) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.07 Pain Relevance 0
The presence of clusters of corneal progenitor cells in conjunctiva has been reported, and it is possible that the expression of K3 and K12 observed in this study could be due to the proliferation of corneal stem cells in conjunctiva [34].
Gene_expression (expression) of K12 in conjunctiva
10) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Interestingly, conjunctival cultures also expressed cytokeratin K3 and K12.
Gene_expression (expressed) of K12
11) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
The cells did not express cytokeratin K12 or Pax-6, an eye-specific transcription factor.


Neg (not) Gene_expression (express) of K12 in eye
12) Confidence 0.44 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
The oral epithelial cultures did not express cytokeratin K12, indicating that the cells retained the phenotype of oral epithelial cells.
Neg (not) Gene_expression (express) of K12 in epithelial cells
13) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0

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