INT225960

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 2.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT13)
Anatomy Link Frequency
horn 1
intermediate cell layers 1
epidermis 1
epithelial cells 1
stratified squamous epithelial cells 1
KRT13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 5.00 Very Low Very Low Very Low
medulla 35 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Chronic pancreatitis 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
cryotherapy 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 425 100.00 Very High Very High Very High
Transitional Cell Carcinoma 45 91.52 High High
Targeted Disruption 98 85.40 High High
Skin Cancer 145 84.08 Quite High
Recurrence 5 79.12 Quite High
Small Cell Lung Carcinoma 5 77.24 Quite High
Neuroendocrine Cancer 20 74.96 Quite High
Carcinoma 110 71.24 Quite High
Metaplasia 20 65.80 Quite High
Lung Cancer 30 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Keratin K13 is also expressed in the urothelium as a major component of the basal and intermediate cells whereas it is lost in the superficial umbrella cells (that switch on K20 expression; see above).
Gene_expression (expressed) of K13
1) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.05 Pain Relevance 0
Interestingly, K4/K13 is completely absent in the epidermis and adnexal structures.
Neg (absent) Gene_expression (absent) of K13 in epidermis
2) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.06 Pain Relevance 0
Our studies indicate that the three cultures express markers of stratified epithelia such as cytokeratin K3, K4, K13, K15, and connexin 43.
Gene_expression (express) of K13
3) Confidence 0.37 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.07 Pain Relevance 0
Particularly characteristic are K13 expressed in the basal and intermediate cell layers and K20 specific for the superficial (umbrella) cell layer.
Gene_expression (expressed) of K13 in intermediate cell layers
4) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.11 Pain Relevance 0
K4/K13: keratins of mucosal stratified squamous epithelial cells
Gene_expression (/) of K13 in stratified squamous epithelial cells
5) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.14 Pain Relevance 0
RT–PCR analysis showed that cultured oral epithelial cells expressed markers of epithelial differentiation such as cytokeratin K3, K4, K13, K15 and connexin 43.
Gene_expression (expressed) of K13 in epithelial cells
6) Confidence 0.29 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Focally, there may be expression of K1/K10 (particularly in higher differentiated tumor cells which can end in the formation of horn pearls), and—to a lesser extent—K4 and K13.
Gene_expression (expression) of K13 in horn associated with cancer
7) Confidence 0.27 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.04 Pain Relevance 0
The cells also expressed cytokeratin K4 and K13, markers of nonkeratinized stratified oral epithelia [23,24] as seen earlier in rabbit oral epithelial cultures [16].
Gene_expression (expressed) of K13
8) Confidence 0.25 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0

General Comments

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