INT225965

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Context Info
Confidence 0.81
First Reported 2008
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 26
Total Number 32
Disease Relevance 18.85
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
retina 4
astrocytes 3
Spinal cord 2
brain 2
CNS 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 800 100.00 Very High Very High Very High
potassium channel 23 100.00 Very High Very High Very High
Spinal cord 364 99.90 Very High Very High Very High
Neuritis 327 98.08 Very High Very High Very High
cva 84 95.72 Very High Very High Very High
Inflammation 221 95.44 Very High Very High Very High
ischemia 42 88.56 High High
medulla 39 85.24 High High
imagery 194 82.16 Quite High
Hippocampus 13 76.08 Quite High
Disease Link Frequency Relevance Heat
Brain Disease 14 99.92 Very High Very High Very High
Neuromyelitis Optica 2803 99.90 Very High Very High Very High
Ocular Hypertension 167 99.84 Very High Very High Very High
Refractive Errors 101 99.76 Very High Very High Very High
Pressure And Volume Under Development 42 99.36 Very High Very High Very High
Disease 702 99.00 Very High Very High Very High
Infection 247 98.48 Very High Very High Very High
Transverse Myelitis 184 98.44 Very High Very High Very High
Optic Neuritis 314 98.08 Very High Very High Very High
Hydrocephalus 301 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IF-stained sections (five from each group) were analysed qualitatively regarding co-localisation of GFAP and AQP4, and AQP4 expression in relation to lectin staining, blinded by one observer (ADS).
Localization (localisation) of AQP4
1) Confidence 0.81 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0 Pain Relevance 0.04
Our data confirm astrocytic and ependymal cell localization of AQP4 in both normal brain and in hydrocephalic brain pathology.
Localization (localization) of AQP4 in brain associated with brain disease
2) Confidence 0.81 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.66 Pain Relevance 0
AQP4 co-localizes with astrocytic GFAP in both glia limitans and perivascular end feet.
Localization (localizes) of AQP4
3) Confidence 0.81 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.64 Pain Relevance 0
In vascular structures, AQP4 co-localized to astroglia but not to endothelial cells.
Neg (not) Localization (localized) of AQP4 in endothelial cells
4) Confidence 0.81 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.28 Pain Relevance 0
The possible involvement of aquaporins as mediator of the water flux associated with K+ transfer was originally suggested by Nagelhus and his coworkers [21,62], who demonstrated the polarized colocalization of Kir4.1 potassium channels and AQP4 on Müller cell processes facing the vitreous and blood vessels in the rat retina [22].
Localization (colocalization) of AQP4 in blood vessels associated with potassium channel
5) Confidence 0.80 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.22 Pain Relevance 0.08
The localization of AQP4 seen predominantly in the innermost layers in chick retina bears striking similarity to that previously described in the rat retina [7,16,21] and matches the known morphology of the chick Müller cell [51,52].
Localization (localization) of AQP4 in retina
6) Confidence 0.80 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.22 Pain Relevance 0
Typically, these retinal regions of co-localized Kir4.1 and AQP4 channels act as potassium [K+] sinks for regulating high concentrations of [K+] in the extracellular space around active neurons [21,22].
Localization (localized) of AQP4 in neurons
7) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.25 Pain Relevance 0.09
Our observation of decreased abundance of AQP4 in the periventricular region after two days of hydrocephalus coincide with symptoms indicative of raised intracranial pressure (ICP) as judged by clinical symptoms.
Localization (abundance) of AQP4 associated with intracranial hypertension, hydrocephalus and cva
8) Confidence 0.75 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.70 Pain Relevance 0.21
Five out of 7 rats (71%) showed a significant reduction in mRNA (54±11%, p<0.001 versus HEPES-injected or control, Figure 2A), and there was a similar reduction in AQP4 mRNA upon elevation of IOP in six out nine rats (67%, 62±12, p=0.001, Figure 2B).
Localization (elevation) of AQP4 mRNA associated with ocular hypertension
9) Confidence 0.73 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.93 Pain Relevance 0
AQP4 and Kir4.1 protein expression in the retina
Localization (retina) of AQP4 in retina
10) Confidence 0.72 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.19 Pain Relevance 0
Immunolocalization of AQP4 and Kir4.1 channel expression in the normal chick retina
Localization (Immunolocalization) of AQP4 in retina
11) Confidence 0.72 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.22 Pain Relevance 0
For retinal AQP4 and Kir4.1, it was 45 cycles of denaturation at 95 °C for 30 s, annealing at 60 °C for 30 s, and extension at 72 °C for 1 min.
Localization (retinal) of AQP4
12) Confidence 0.71 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0 Pain Relevance 0
As shown in Figure 2A, ONC resulted in a decrease in AQP4 protein (60±10, 63±10, and 38±10, p<0.001 at days 2, 7, and 14, respectively, Figure 2A,B, n=7), and there as a similar reduction in AQP4 mRNA (~40%), as determined by Q-PCR (61±5%, 60±8%, and 58±6 at days 2, 7, and 14, respectively, p<0.001 versus control, Figure 2B, n=7).
Localization (decrease) of AQP4
13) Confidence 0.71 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.36 Pain Relevance 0.03
In vascular structures, AQP4 co-localized to astroglia but not to microglia or endothelial cells.


Neg (not) Localization (localized) of AQP4 in microglia
14) Confidence 0.71 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2987763 Disease Relevance 0.33 Pain Relevance 0.05
By contrast, IOP enhanced expression and co-localization of GFAP and AQP4 in optic nerve astrocytes.
Localization (localization) of AQP4 in astrocytes associated with ocular hypertension
15) Confidence 0.69 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.75 Pain Relevance 0
While the labeling of AQP4 and Kir4.1 was predominantly found in similar regions of the retina, the localization of the greatest intensity of AQP4 and Kir4.1 labeling differed within the chick retina.
Localization (localization) of AQP4 in retina
16) Confidence 0.68 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.25 Pain Relevance 0
Spatial co-localization of aquaporin water channels (AQP4) and inwardly rectifying potassium ion channels (Kir4.1) on the endfeet regions of glial cells has been suggested as the basis of functionally interrelated mechanisms of osmoregulation in brain edema.
Localization (localization) of AQP4 in glial cells associated with pressure and volume under development
17) Confidence 0.68 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927440 Disease Relevance 0.26 Pain Relevance 0
The primers for retinal AQP4 were 5?
Localization (retinal) of AQP4
18) Confidence 0.62 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0 Pain Relevance 0
Thus the binding of human NMO-IgG to murine AQP4 suggests at least three interpretations: 1) that Loop A is not a B cell epitope, 2) the changes between rodents and humans do not affect antibody binding if the loop A sequence is a B cell epitope., or 3) the sequence changes do affect binding of anti-AQP4 antibodies, but other AQP4 epitopes are still available and antibodies in polyclonal sera have enough reactivity to AQP4 to be scored as positive for binding if one AQP4 epitope is compromised.
Localization (murine) of AQP4 in B cell associated with neuromyelitis optica
19) Confidence 0.62 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.33 Pain Relevance 0.04
In many of the cases of parainfectious NMO the presence of AQP4-specific antibodies is not reported and some CSF profiles are not consistent with NMO.
Localization (presence) of AQP4 associated with neuromyelitis optica
20) Confidence 0.62 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.47 Pain Relevance 0.13

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