INT225966

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 18
Total Number 32
Disease Relevance 20.39
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
brain 12
retina 8
lymphocytes 4
blood 2
glial cell 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 446 100.00 Very High Very High Very High
Inflammatory mediators 7 99.84 Very High Very High Very High
Inflammation 134 99.68 Very High Very High Very High
imagery 326 99.28 Very High Very High Very High
cva 156 99.16 Very High Very High Very High
cytokine 35 98.84 Very High Very High Very High
ischemia 57 92.28 High High
medulla 21 85.76 High High
Spinal cord 210 80.56 Quite High
tolerance 21 77.60 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 1548 99.88 Very High Very High Very High
Hydrocephalus 559 99.84 Very High Very High Very High
INFLAMMATION 138 99.84 Very High Very High Very High
Edema 260 99.70 Very High Very High Very High
Targeted Disruption 140 99.52 Very High Very High Very High
Injury 135 99.24 Very High Very High Very High
Intracranial Hypertension 91 99.16 Very High Very High Very High
Disease 407 99.14 Very High Very High Very High
Refractive Errors 84 99.00 Very High Very High Very High
Infection 133 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies indicate that altered AQP4 expression is rate-limiting for brain water transport and edema implying that altered AQP4 expression maybe functionally significant in cases of disturbed CSF circulation.
Spec (maybe) Regulation (altered) of Gene_expression (expression) of AQP4 in brain associated with edema
1) Confidence 0.62 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.05 Pain Relevance 0.10
These studies indicate that altered AQP4 expression is rate-limiting for brain water transport and edema implying that altered AQP4 expression maybe functionally significant in cases of disturbed CSF circulation.
Regulation (altered) of Gene_expression (expression) of AQP4 in brain associated with edema
2) Confidence 0.62 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.29 Pain Relevance 0.10
If AQP4 does indeed play such a role in osmotic and hydrostatic-related functions of the retina, we would expect to see changes in the AQP4 expression in Müller cells in any ocular disorder characterized by abnormalities of retinal hydration or changes in vitreal volume such as in refractive errors like myopia and hyperopia [29].
Regulation (changes) of Gene_expression (expression) of AQP4 in retina associated with hyperopia, refractive errors, congenital anomalies and myopia
3) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 1.12 Pain Relevance 0
The results of the present study showing a change in the expression of both AQP4 and Kir4.1 channels during imposed optical defocus provides further support for the involvement of osmoregulatory mechanisms in ocular growth.
Regulation (change) of Gene_expression (expression) of AQP4
4) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.51 Pain Relevance 0
Correlation between periventricular AQP4 expression and quantitative MRI
Regulation (Correlation) of Gene_expression (expression) of AQP4 associated with imagery
5) Confidence 0.45 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.19 Pain Relevance 0.05
Furthermore, AQP4 knockout mice have been used to determine the potentially important relationship between the rapid movement of water during retinal signal transduction and AQP4 expression on Müller cell membranes [22].
Spec (determine) Regulation (determine) of Gene_expression (expression) of AQP4 associated with targeted disruption
6) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.31 Pain Relevance 0.03
Therefore, the effect of intravitreal injection of ET-1 on AQP4 expression in retina was tested.
Regulation (effect) of Gene_expression (expression) of AQP4 in retina
7) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.05 Pain Relevance 0
Pattern of AQP4 immunoreactivity during the induction of refractive error by optical defocus
Regulation (Pattern) of Gene_expression (immunoreactivity) of AQP4 associated with refractive errors
8) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.40 Pain Relevance 0
Therefore, the effect of ONC on AQP4 expression in retina was tested.
Regulation (effect) of Gene_expression (expression) of AQP4 in retina
9) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.43 Pain Relevance 0
We consider that changes in ADC values and AQP4 represent phases of ICP changes following hydrocephalus development.
Regulation (changes) of Gene_expression (values) of AQP4 associated with hydrocephalus and cva
10) Confidence 0.39 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.00 Pain Relevance 0.30
If the NMO model is consistent with the human disease, it can be used to examine how changes in AQP4 expression and blood-brain barrier (BBB) integrity, both of which can be regulated by CNS inflammation, contribute to inductive events for anti-AQP4-specific immune response.
Regulation (regulated) of Gene_expression (expression) of AQP4 in blood associated with neuromyelitis optica, inflammation, central nervous system and disease
11) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.75 Pain Relevance 0.23
AQP4 expression in endothelial cells (not a major pool of AQP4 expression) is maintained while the AQP4 in astrocyte end feet is lost [33].
Regulation (pool) of Gene_expression (expression) of AQP4 in astrocyte
12) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.31 Pain Relevance 0.05
Ependyma and AQP4 distribution
Regulation (Ependyma) of Gene_expression (distribution) of AQP4
13) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.46 Pain Relevance 0.38
No change in AQP4 expression was found in the periaqueductal region at any time.


Neg (No) Regulation (change) of Gene_expression (expression) of AQP4
14) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.16 Pain Relevance 0
Hence our objective was to study the spatiotemporal changes in brain AQP4 expression during experimental hydrocephalus relative to healthy physiological conditions.


Regulation (changes) of Gene_expression (expression) of AQP4 in brain associated with hydrocephalus
15) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.42 Pain Relevance 0.12
We hypothesized that changes in AQP4 expression in specific brain regions correspond to the severity and duration of hydrocephalus.


Regulation (changes) of Gene_expression (expression) of AQP4 in brain associated with hydrocephalus
16) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2987763 Disease Relevance 0.26 Pain Relevance 0.08
The present study shows regional- and time-dependent regulation of AQP4 expression in experimental hydrocephalus.
Regulation (regulation) of Gene_expression (expression) of AQP4 associated with hydrocephalus
17) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.48 Pain Relevance 0.04
Expression levels of AQP4 could possibly influence resolution of interstitial hydrocephalic edema and drainage of excess ventricular CSF.
Regulation (influence) of Gene_expression (Expression) of AQP4 associated with edema
18) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.25 Pain Relevance 0
Whilst our data also suggest disorganisation of the ependyma as well as changes in AQP4 expression, our study design does not allow us to address any specific correlation.
Regulation (changes) of Gene_expression (expression) of AQP4
19) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.69 Pain Relevance 0
In this study we hypothesized that changes in AQP4 expression in specific brain regions correspond to the severity and duration of hydrocephalus.
Regulation (changes) of Gene_expression (expression) of AQP4 in brain associated with hydrocephalus
20) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.33 Pain Relevance 0.05

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