INT22597

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 43
Total Number 44
Disease Relevance 27.27
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TF) extracellular region (TF) cytoplasmic membrane-bounded vesicle (TF)
transmembrane transport (TF)
Anatomy Link Frequency
plasma 4
blood 3
monocyte 2
urine 2
pancreas 1
TF (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 25 100.00 Very High Very High Very High
Cluster headache 3 99.42 Very High Very High Very High
Inflammation 190 99.28 Very High Very High Very High
Analgesic 3 99.08 Very High Very High Very High
cINOD 6 99.00 Very High Very High Very High
Angina 79 98.92 Very High Very High Very High
Paracetamol 6 98.04 Very High Very High Very High
local anesthetic 1 97.48 Very High Very High Very High
headache 7 93.48 High High
cytokine 53 90.88 High High
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 207 99.84 Very High Very High Very High
Myocardial Infarction 403 99.82 Very High Very High Very High
Hypoxia 3 99.82 Very High Very High Very High
Acute Coronary Syndrome 202 99.76 Very High Very High Very High
Cluster Headache 3 99.42 Very High Very High Very High
INFLAMMATION 218 99.28 Very High Very High Very High
Disease 120 99.28 Very High Very High Very High
Cv General 3 Under Development 58 98.92 Very High Very High Very High
Chronic Renal Failure 66 98.88 Very High Very High Very High
Sepsis 35 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with unstable angina had shortened mean baseline clotting time (284 +/- 86, n = 13) compared with healthy volunteers (474 +/- 98, n = 30), suggesting that these patients had elevated levels of circulating TF.
Positive_regulation (elevated) of TF associated with coagulation disorder and angina
1) Confidence 0.68 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 10744152 Disease Relevance 0.96 Pain Relevance 0.17
In patients with AMI, plasma TF activity was significantly increased in those that died compared to those that survived, while in patients with uAP no such association was observed.
Positive_regulation (increased) of TF in plasma associated with myocardial infarction
2) Confidence 0.68 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.61 Pain Relevance 0
Here, we report that a family of anti-inflammatory agents, known as the salicylates, inhibited LPS induction of TF activity and TF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses.
Positive_regulation (induction) of TF in THP-1 associated with inflammation
3) Confidence 0.68 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.35 Pain Relevance 0.17
In contrast, two other nonsteroidal anti-inflammatory drugs, ibuprofen and indomethacin, did not inhibit LPS induction of the TF gene.
Positive_regulation (induction) of TF gene associated with inflammation and cinod
4) Confidence 0.68 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.32 Pain Relevance 0.21
Serum iron and serum transferrin were low, but serum ferritin concentration and transferrin saturation were increased to the maximum.
Positive_regulation (increased) of transferrin
5) Confidence 0.62 Published 2001 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 11252417 Disease Relevance 1.00 Pain Relevance 0.16
Her cousin, a 33-year-old man who had had episodic cluster headache for several years, also had increased transferrin saturation and was compound heterozygous for two mutations, a genotype known to be associated with a slightly increased frequency of haemochromatosis.
Positive_regulation (increased) of transferrin associated with cluster headache and iron overload
6) Confidence 0.62 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12100096 Disease Relevance 0.93 Pain Relevance 0.69
The increase in TF activity observed in the present study, might reflect a systemic hypercoagulable state [29,30].
Positive_regulation (increase) of TF associated with thrombophilia
7) Confidence 0.59 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.82 Pain Relevance 0.09
Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide (LPS) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the TF promoter.
Positive_regulation (activation) of TF gene
8) Confidence 0.59 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.33 Pain Relevance 0.15
The promotion of myogenesis requires transferrin (Tf) which transports Fe to the cells.
Positive_regulation (requires) of Tf
9) Confidence 0.55 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2310774 Disease Relevance 0 Pain Relevance 0.10
This is the first study to address the issue of whether circulating TF activity has an impact on cardiovascular mortality in patients with ACS.
Spec (whether) Positive_regulation (circulating) of TF associated with acute coronary syndrome
10) Confidence 0.49 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.61 Pain Relevance 0
Although the clinical relevance of circulating TF activity is still a matter of debate, our data together with these publications underline the pathophysiological relevance of circulating TF in coronary atherothrombosis.
Positive_regulation (circulating) of TF
11) Confidence 0.49 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.37 Pain Relevance 0
Although the clinical relevance of circulating TF activity is still a matter of debate, our data together with these publications underline the pathophysiological relevance of circulating TF in coronary atherothrombosis.
Positive_regulation (circulating) of TF
12) Confidence 0.49 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.49 Pain Relevance 0.03
In contrast, in patients with uAP, circulating TF activity was not related to the long term prognosis.
Positive_regulation (circulating) of TF
13) Confidence 0.49 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.61 Pain Relevance 0
Our data corroborate the hypothesis that circulating TF presents a high risk blood condition that is prone to thrombosis.
Positive_regulation (circulating) of TF in blood associated with thrombosis
14) Confidence 0.49 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.31 Pain Relevance 0
Patients were categorized into 2 groups: a high-TF activity group with TF >24 pmol/L and low TF activity group with TF ?
Positive_regulation (high) of TF
15) Confidence 0.49 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2714503 Disease Relevance 0.93 Pain Relevance 0.09
[The influence of the bioflanoid dicvertin on the antioxidative system ceruloplasmin-transferrin and lipid peroxidation in patients suffering from stable coronary heart disease with dyslipidemia].
Positive_regulation (antioxidative) of transferrin in heart associated with coronary artery disease
16) Confidence 0.49 Published 2006 Journal Klin Med (Mosk) Section Title Doc Link 16924801 Disease Relevance 0.46 Pain Relevance 0.09
Treatment with rhGH has been shown to reduce protein catabolism,13,14 increase muscle area and strength,14–18 increase erythropoietin synthesis,19 and to improve inflammation status and quality of life.20 A recent 6-month study showed a positive effect of GH treatment on lean body mass and cardiovascular risk factors.21 Furthermore, GH administration is associated with improvements in several nutritional parameters, such as increases in serum insulin-like growth factor-I (IGF-I),13,14,22 serum albumin14 and transferrin,13 and a reduction in blood urea nitrogen.13
Positive_regulation (increases) of transferrin in blood associated with inflammation
17) Confidence 0.49 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.53 Pain Relevance 0.05
The serum levels of iron, transferrin saturation and feritin were markedly elevated.
Positive_regulation (elevated) of transferrin
18) Confidence 0.47 Published 1999 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 10071604 Disease Relevance 0.18 Pain Relevance 0
No TF activity was detected in the supernatant using the assay for MP-bound TF activity (Figure 2E, J).
Positive_regulation (detected) of TF
19) Confidence 0.45 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.17 Pain Relevance 0
In contrast to patients with ongoing ACS, almost no TF activity was detected in the circulation of sAP patients (0.0 ± 0.0 pmol vs 0.5 ± 0.16 pmol, P = 0.008, Table 4), even after abrogating the endogenous inhibition by TFPI-1 (0.98 ± 0.4 pmol vs 12.63 ± 1.82 pmol, P < 0.001).
Positive_regulation (detected) of TF associated with acute coronary syndrome
20) Confidence 0.45 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.75 Pain Relevance 0.11

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