INT225973

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb1) plasma membrane (Itgb1)
Anatomy Link Frequency
microglial cell 1
Itgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
dopaminergic neurodegeneration 1 98.08 Very High Very High Very High
cytokine 8 79.60 Quite High
Inflammation 42 79.20 Quite High
midbrain 12 28.72 Quite Low
cINOD 27 5.00 Very Low Very Low Very Low
Dopamine 21 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 98.40 Very High Very High Very High
Parkinson's Disease 108 96.56 Very High Very High Very High
Toxicity 15 95.68 Very High Very High Very High
Cataract 59 82.64 Quite High
INFLAMMATION 52 79.20 Quite High
Genomic Instability 1 43.48 Quite Low
Aids-related Complex 11 31.52 Quite Low
Targeted Disruption 2 12.56 Low Low
Drug Induced Neurotoxicity 10 12.36 Low Low
Disease 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The work of Yao et al. [61] suggests that the migration defect may involve interactions between integrin beta-1, TGF-?
integrin beta-1 Binding (interactions) of
1) Confidence 0.08 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254966 Disease Relevance 0.41 Pain Relevance 0
Changes in activated microglial cell number and morphologic appearance at both striatal and SNpc levels were assessed using Mac-1-Ab, an integrin receptor known to mediate reactive microgliosis and recognized to significantly contribute to the progressive dopaminergic neurodegeneration in the MPTP model of DAergic toxicity, both in vivo and in vitro [see [28-33] and background].
integrin receptor Binding (recognized) of in microglial cell associated with parkinson's disease, toxicity and dopaminergic neurodegeneration
2) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.69 Pain Relevance 0.20

General Comments

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