INT225981
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Recent data has found an association of XRCC1 with proteins causally linked to human spinocerebellar ataxiasaprataxin and tyrosyl-DNA phosphodiesterase 1implicating SSBR in protection against neuronal cell loss and neurodegenerative disease. | |||||||||||||||
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The initially incurred DNA strand breaks were repaired within 30 min, but DNA damage remained as shown 72 h post-irradiation by the presence of the DNA adduct, 8-hydroxyguanosine (8-OHG), and a DNA repair protein, XRCC1. | |||||||||||||||
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PARP-1 has been reported to play a key role in the nucleotide excision repair (NER) pathway used to remove bulky DNA adducts [74] and in the base excision repair (BER) pathway by interacting with BER protein XRCC1 (X-ray repair cross-complementing 1) [7578]. | |||||||||||||||
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PARP-1 has been reported to play a key role in the nucleotide excision repair (NER) pathway used to remove bulky DNA adducts [74] and in the base excision repair (BER) pathway by interacting with BER protein XRCC1 (X-ray repair cross-complementing 1) [7578]. | |||||||||||||||
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General Comments
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