INT225981

Context Info Confidence 0.36 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.81 Pain Relevance 0

nucleus (Xrcc1) intracellular (Xrcc1)

Anatomy Link Frequency neuronal 1 Xrcc1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 14 5.00 Inflammatory response 4 5.00 anesthesia 2 5.00 headache 2 5.00 bDMF 1 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Spinocerebellar Ataxia Type 2 3 98.40 Neurodegenerative Disease 3 93.12 Cataract 59 90.88 Targeted Disruption 8 84.72 Neuroblastoma 4 77.20 Aneuploidy 2 49.76 Genomic Instability 23 42.00 Apoptosis 52 25.00 Cancer 63 5.00 Stress 26 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recent data has found an association of XRCC1 with proteins causally linked to human spinocerebellar ataxias—aprataxin and tyrosyl-DNA phosphodiesterase 1—implicating SSBR in protection against neuronal cell loss and neurodegenerative disease.

XRCC1 Binding (association) of in neuronal associated with spinocerebellar ataxia type 2 and neurodegenerative disease

1) Confidence 0.36 Published 2008 Journal Nucleic Acids Research Section Abstract Doc Link PMC2528184 Disease Relevance 0.27 Pain Relevance 0

The initially incurred DNA strand breaks were repaired within 30 min, but DNA damage remained as shown 72 h post-irradiation by the presence of the DNA adduct, 8-hydroxyguanosine (8-OHG), and a DNA repair protein, XRCC1.

XRCC1 Binding (presence) of

2) Confidence 0.30 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254966 Disease Relevance 0.38 Pain Relevance 0

PARP-1 has been reported to play a key role in the nucleotide excision repair (NER) pathway used to remove bulky DNA adducts [74] and in the base excision repair (BER) pathway by interacting with BER protein XRCC1 (X-ray repair cross-complementing 1) [75–78].

XRCC1 Binding (interacting) of

3) Confidence 0.13 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.08 Pain Relevance 0

PARP-1 has been reported to play a key role in the nucleotide excision repair (NER) pathway used to remove bulky DNA adducts [74] and in the base excision repair (BER) pathway by interacting with BER protein XRCC1 (X-ray repair cross-complementing 1) [75–78].

repair cross-complementing 1 Binding (interacting) of

4) Confidence 0.11 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.