INT225981

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xrcc1) intracellular (Xrcc1)
Anatomy Link Frequency
neuronal 1
Xrcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
bDMF 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinocerebellar Ataxia Type 2 3 98.40 Very High Very High Very High
Neurodegenerative Disease 3 93.12 High High
Cataract 59 90.88 High High
Targeted Disruption 8 84.72 Quite High
Neuroblastoma 4 77.20 Quite High
Aneuploidy 2 49.76 Quite Low
Genomic Instability 23 42.00 Quite Low
Apoptosis 52 25.00 Low Low
Cancer 63 5.00 Very Low Very Low Very Low
Stress 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent data has found an association of XRCC1 with proteins causally linked to human spinocerebellar ataxias—aprataxin and tyrosyl-DNA phosphodiesterase 1—implicating SSBR in protection against neuronal cell loss and neurodegenerative disease.
XRCC1 Binding (association) of in neuronal associated with spinocerebellar ataxia type 2 and neurodegenerative disease
1) Confidence 0.36 Published 2008 Journal Nucleic Acids Research Section Abstract Doc Link PMC2528184 Disease Relevance 0.27 Pain Relevance 0
The initially incurred DNA strand breaks were repaired within 30 min, but DNA damage remained as shown 72 h post-irradiation by the presence of the DNA adduct, 8-hydroxyguanosine (8-OHG), and a DNA repair protein, XRCC1.
XRCC1 Binding (presence) of
2) Confidence 0.30 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254966 Disease Relevance 0.38 Pain Relevance 0
PARP-1 has been reported to play a key role in the nucleotide excision repair (NER) pathway used to remove bulky DNA adducts [74] and in the base excision repair (BER) pathway by interacting with BER protein XRCC1 (X-ray repair cross-complementing 1) [75–78].
XRCC1 Binding (interacting) of
3) Confidence 0.13 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.08 Pain Relevance 0
PARP-1 has been reported to play a key role in the nucleotide excision repair (NER) pathway used to remove bulky DNA adducts [74] and in the base excision repair (BER) pathway by interacting with BER protein XRCC1 (X-ray repair cross-complementing 1) [75–78].
repair cross-complementing 1 Binding (interacting) of
4) Confidence 0.11 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.08 Pain Relevance 0

General Comments

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