INT225984

Context Info Confidence 0.08 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 4.77 Pain Relevance 0.47

[[Del(7)Tyr<c-1DThWb>-p]] (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 38 91.20 cytokine 36 90.16 tolerance 17 79.24 anesthesia 4 5.00 corticosteroid 2 5.00 cINOD 2 5.00 Inflammatory response 2 5.00 isoflurane 2 5.00 imagery 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 95 100.00 Viral Infection 2 98.88 Ocular Injury 58 93.60 INFLAMMATION 42 91.20 Cold Sores 106 89.80 Reprotox - General 1 4 86.04 Injury 16 84.08 Uveitis 2 81.76 Infection 78 77.24 Keratitis 74 70.76

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Event

Anatomy

Negation

Speculation

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Disease term

It is also important to point out that CD8+ Treg, known to suppress the expression of DTH in ACAID [20], were also presumably generated in the current study.

Gene_expression (expression) of DTH associated with hypersensitivity

1) Confidence 0.08 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.10 Pain Relevance 0

As the absence of a DTH response is a crucial characteristic in ACAID, we evaluated the induction of ACAID by measuring the DTH response in mice following various treatments.

Gene_expression (response) of DTH associated with hypersensitivity

2) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 1.16 Pain Relevance 0.15

The results showed that a DTH response was readily detected in positive controls and PBS controls but not in the AC-injection group or in the normal, untreated controls.

Gene_expression (response) of DTH associated with hypersensitivity

3) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 1.15 Pain Relevance 0.15

This was also supported by our results for DTH responses in the mice.

Gene_expression (responses) of DTH associated with hypersensitivity

4) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.48 Pain Relevance 0.13

The DTH responses in all infected groups were significantly higher than uninfected controls (p<0.01).

Gene_expression (responses) of DTH associated with hypersensitivity

5) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.89 Pain Relevance 0.04

General Comments

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