INT225988

Context Info Confidence 0.03 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 9 Disease Relevance 8.79 Pain Relevance 0.58

Anatomy Link Frequency eye 1 [[Del(7)Tyr<c-1DThWb>-p]] (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 80 91.20 cytokine 82 90.72 tolerance 25 69.84 imagery 4 10.72 anesthesia 5 5.00 isoflurane 5 5.00 corticosteroid 4 5.00 cINOD 4 5.00 Inflammatory response 4 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 195 100.00 Cold Sores 212 99.32 Infection 156 99.08 Injury 40 98.36 Ocular Injury 145 95.84 Viral Infection 4 93.04 Pressure And Volume Under Development 37 92.56 Corneal Neovascularization 4 92.28 INFLAMMATION 88 91.20 Corneal Opacity 16 91.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Treatment with pBTLA suppresses the systemic DTH responses of mice

Regulation (responses) of DTH associated with hypersensitivity

1) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.83 Pain Relevance 0.03

A significantly decreased DTH response was observed in the AC-injection group as well as in mice that received a penetrating injury at 72 h and 120 h following AC-injection of OVA.

Regulation (response) of DTH associated with injury and hypersensitivity

2) Confidence 0.02 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2255028 Disease Relevance 0.67 Pain Relevance 0

A significant DTH response was also observed in the 24 h and 48 h “injury” group but not in the 72-h and 120-h group.

Regulation (response) of DTH associated with injury and hypersensitivity

3) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 1.12 Pain Relevance 0.13

Similarly, a strong DTH response was also noted in the PBS control group (Figure 2).

Regulation (response) of DTH associated with hypersensitivity

4) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.60 Pain Relevance 0.08

These results indicate that the breakdown of the eye’s integrity at an early stage following an AC injection could induce a DTH response and was able to prevent the induction of ACAID.

Regulation (response) of DTH in eye associated with hypersensitivity

5) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.92 Pain Relevance 0.12

The results showed that an AC injection of OVA could induce a decreased DTH response in association with an increased production of TGF-?

Regulation (response) of DTH associated with hypersensitivity

6) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.73 Pain Relevance 0.03

This was also supported by our results for DTH responses in the mice.

Regulation (responses) of DTH associated with hypersensitivity

7) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.48 Pain Relevance 0.13

DTH responses were measured in uninfected (naïve) and infected mice, including treated and control groups, on day 13 after HSV-1 infection.

Regulation (responses) of DTH associated with cold sores, hypersensitivity and infection

8) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.53 Pain Relevance 0

The pBTLA treated mice showed an impaired DTH response two weeks after HSV-1 infection compared to control mice.

Regulation (response) of DTH associated with cold sores, hypersensitivity and infection

9) Confidence 0.02 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2965573 Disease Relevance 0.90 Pain Relevance 0.04

General Comments

This test has worked.