INT2260

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Context Info
Confidence 0.49
First Reported 1979
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 7.05
Pain Relevance 11.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
spinal cord 3
plasma 2
blood 1
hair follicles 1
skin 1
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 17 100.00 Very High Very High Very High
melanocortin 1 receptor 6 99.88 Very High Very High Very High
Spinal cord 60 99.84 Very High Very High Very High
Dopamine 111 99.80 Very High Very High Very High
Dorsal horn 32 99.68 Very High Very High Very High
Sciatic nerve 1 99.12 Very High Very High Very High
agonist 7 99.00 Very High Very High Very High
Clonidine 7 98.98 Very High Very High Very High
diclofenac 70 98.70 Very High Very High Very High
Hyperalgesia 117 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Immunization 24 100.00 Very High Very High Very High
Shock 3 98.80 Very High Very High Very High
Hypotension 3 98.28 Very High Very High Very High
Hyperalgesia 138 98.16 Very High Very High Very High
Headache 10 97.84 Very High Very High Very High
Appetite Loss 10 97.80 Very High Very High Very High
Neuroblastoma 12 96.08 Very High Very High Very High
Neuropathic Pain 27 93.48 High High
Body Weight 13 93.20 High High
INFLAMMATION 13 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, Tyr-Gly-Gly production was elevated by blood sampling alone, by handling/novelty, and by training, but the effect of training was significantly greater than the effects of either of the other treatments.
Gene_expression (production) of Tyr in blood
1) Confidence 0.49 Published 1993 Journal Peptides Section Abstract Doc Link 8483796 Disease Relevance 0.10 Pain Relevance 0.39
Interestingly, Tyr-Gly-Gly production was highly correlated (r = -0.885) with a measure of escape performance.
Gene_expression (production) of Tyr
2) Confidence 0.49 Published 1993 Journal Peptides Section Abstract Doc Link 8483796 Disease Relevance 0.09 Pain Relevance 0.38
Avoidance training increased Tyr production, as did handling and exposing animals to the novel avoidance chamber without foot-shock training.
Gene_expression (production) of Tyr in foot associated with shock
3) Confidence 0.49 Published 1993 Journal Peptides Section Abstract Doc Link 8483796 Disease Relevance 0.10 Pain Relevance 0.39
The production of Tyr was completely inhibited by bestatin, an inhibitor of aminopeptidases, that of Tyr-Gly-Gly by thiorphan, a specific inhibitor of enkephalinase A.
Gene_expression (production) of Tyr
4) Confidence 0.46 Published 1983 Journal FEBS Lett. Section Abstract Doc Link 6337881 Disease Relevance 0 Pain Relevance 0.17
The incubation experiments with a cell suspension revealed Tyr as the main tritiated metabolite; however, Tyr-Gly-Gly and Tyr-Gly were detectable as well.
Gene_expression (detectable) of Tyr-Gly
5) Confidence 0.46 Published 1983 Journal FEBS Lett. Section Abstract Doc Link 6337881 Disease Relevance 0 Pain Relevance 0.16
The incubation experiments with a cell suspension revealed Tyr as the main tritiated metabolite; however, Tyr-Gly-Gly and Tyr-Gly were detectable as well.
Gene_expression (detectable) of Tyr-Gly
6) Confidence 0.46 Published 1983 Journal FEBS Lett. Section Abstract Doc Link 6337881 Disease Relevance 0 Pain Relevance 0.16
Natural or synthetic melanin (CAS 8049-97-6) is a high molecular weight heteropolymer, product of the enzyme tyrosinase, found to possess radical scavenging and antioxidant functions.
Gene_expression (product) of tyrosinase
7) Confidence 0.41 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9706378 Disease Relevance 0.62 Pain Relevance 0.14
A series of N-terminal phosphonate derivatives, H2O3PCHPhNHR (R = Leu, Phe, Trp, and/or Tyr), were synthesized with the aim of mimicking phosphoramidon, a potent inhibitor of enkephalinase, while avoiding the lability of the scissile P-N bond.
Gene_expression (synthesized) of Tyr
8) Confidence 0.30 Published 1986 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 3520730 Disease Relevance 0 Pain Relevance 0
The synthesis of pseudotetrapeptides H-Tyr-D-Ala-Phe-NH-(CH2)2--NH2 (1a), H-Tyr-D-Ala-Phe-psi (CH2--NH)-Gly-NH2 (2a), H-Tyr-D-Ala-psi (CH2--NH)-Phe-Gly-NH2 (3a), and H-Tyr-psi (CH2--NH)-D-Ala-Phe-Gly-NH2 (4a), representing the N-terminal tetrapeptide sequence of dermorphin, in which amide bonds are replaced by CH2--NH bond, is described.
Gene_expression (synthesis) of Tyr
9) Confidence 0.20 Published 1992 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1362392 Disease Relevance 0 Pain Relevance 0
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Gene_expression (expression) of tyrosinase in skin associated with melanocortin 1 receptor
10) Confidence 0.19 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.25
In response to DCF treatment the proportion of DOPAC and DA decreased, whereas the proportion of TAs (OCT, TYR, and PEA) increased.
Gene_expression (proportion) of TYR associated with dopamine and diclofenac
11) Confidence 0.18 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2324205 Disease Relevance 0 Pain Relevance 0.60
The synthesis of pseudotetrapeptides H-Tyr-D-Ala-Phe-NH-(CH2)2--NH2 (1a), H-Tyr-D-Ala-Phe-psi (CH2--NH)-Gly-NH2 (2a), H-Tyr-D-Ala-psi (CH2--NH)-Phe-Gly-NH2 (3a), and H-Tyr-psi (CH2--NH)-D-Ala-Phe-Gly-NH2 (4a), representing the N-terminal tetrapeptide sequence of dermorphin, in which amide bonds are replaced by CH2--NH bond, is described.
Gene_expression (synthesis) of Tyr
12) Confidence 0.18 Published 1992 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1362392 Disease Relevance 0 Pain Relevance 0
The synthesis of pseudotetrapeptides H-Tyr-D-Ala-Phe-NH-(CH2)2--NH2 (1a), H-Tyr-D-Ala-Phe-psi (CH2--NH)-Gly-NH2 (2a), H-Tyr-D-Ala-psi (CH2--NH)-Phe-Gly-NH2 (3a), and H-Tyr-psi (CH2--NH)-D-Ala-Phe-Gly-NH2 (4a), representing the N-terminal tetrapeptide sequence of dermorphin, in which amide bonds are replaced by CH2--NH bond, is described.
Gene_expression (synthesis) of Tyr
13) Confidence 0.18 Published 1992 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1362392 Disease Relevance 0 Pain Relevance 0
The synthesis of pseudotetrapeptides H-Tyr-D-Ala-Phe-NH-(CH2)2--NH2 (1a), H-Tyr-D-Ala-Phe-psi (CH2--NH)-Gly-NH2 (2a), H-Tyr-D-Ala-psi (CH2--NH)-Phe-Gly-NH2 (3a), and H-Tyr-psi (CH2--NH)-D-Ala-Phe-Gly-NH2 (4a), representing the N-terminal tetrapeptide sequence of dermorphin, in which amide bonds are replaced by CH2--NH bond, is described.
Gene_expression (synthesis) of Tyr
14) Confidence 0.16 Published 1992 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1362392 Disease Relevance 0 Pain Relevance 0
Synthesis and binding characteristics of [3H] H-Tyr-Ticpsi[CH2-NH] Cha-Phe-OH, a highly specific and stable delta-opioid antagonist.
Gene_expression (Synthesis) of H-Tyr-Ticpsi associated with antagonist and opioid
15) Confidence 0.14 Published 1999 Journal Peptides Section Title Doc Link 10499425 Disease Relevance 0 Pain Relevance 0.47
Incubation of cells in suspension revealed Tyr as the main tritiated metabolite; however, Tyr-Gly-Gly and Tyr-Gly were detectable as well.
Gene_expression (detectable) of Tyr-Gly
16) Confidence 0.12 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6328331 Disease Relevance 0.32 Pain Relevance 0.30
Incubation of cells in suspension revealed Tyr as the main tritiated metabolite; however, Tyr-Gly-Gly and Tyr-Gly were detectable as well.
Gene_expression (detectable) of Tyr-Gly
17) Confidence 0.12 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6328331 Disease Relevance 0.32 Pain Relevance 0.30
The production of Tyr was inhibited by bestatin, an inhibitor of aminopeptidases, and that of Tyr-Gly-Gly by captopril, an inhibitor of angiotensin-converting-enzyme.
Gene_expression (production) of Tyr
18) Confidence 0.12 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6328331 Disease Relevance 0.33 Pain Relevance 0.33
Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.
Gene_expression (ratio) of Tyr in plasma
19) Confidence 0.09 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0
Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.
Gene_expression (ratio) of Tyr in plasma
20) Confidence 0.09 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0

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