INT22605

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 4
Speculated 5
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 7.10
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
uterine 3
brain 2
hypothalamus 2
pituitary 2
stroma 1
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 13 99.60 Very High Very High Very High
adenocard 1 99.52 Very High Very High Very High
Delta opioid receptors 2 97.36 Very High Very High Very High
anesthesia 30 97.16 Very High Very High Very High
dexamethasone 5 96.98 Very High Very High Very High
Nerve growth factor 1 93.40 High High
ketamine 4 91.04 High High
amygdala 34 86.68 High High
depression 2 83.44 Quite High
Dopamine 46 81.24 Quite High
Disease Link Frequency Relevance Heat
Stress 61 100.00 Very High Very High Very High
INFLAMMATION 13 99.60 Very High Very High Very High
Urological Neuroanatomy 11 99.26 Very High Very High Very High
Breast Cancer 15 99.20 Very High Very High Very High
Lordosis 2 98.20 Very High Very High Very High
Decapitation 6 95.20 Very High Very High Very High
Targeted Disruption 75 94.20 High High
Neurodegenerative Disease 1 91.84 High High
Weight Gain 2 91.08 High High
Body Weight 6 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chloral hydrate, urethane, ethanol, meprobamate, diazepam, and chlorpromazine, on the other hand, in anesthetic doses depressed the CO and BP of pithed rats without influencing PR.
Neg (without) Regulation (influencing) of PR
1) Confidence 0.62 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7436631 Disease Relevance 0.14 Pain Relevance 0.11
Thus, we compared the effects of two anesthetics on the concentration of rat uterine ER and PR.
Regulation (effects) of PR in uterine
2) Confidence 0.45 Published 1989 Journal Clin. Chem. Section Abstract Doc Link 2910556 Disease Relevance 0.42 Pain Relevance 0.47
We found though, that DPN treatment caused down regulation of the PR protein level in GE, and indeed it also decreased the PRAB and PRB mRNA levels.
Regulation (regulation) of PR
3) Confidence 0.35 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.23 Pain Relevance 0
mediated effects on PR mRNA levels could be obscured due to the mixture of cell types in the uterine homogenate used for PCR.
Regulation (effects) of PR in uterine
4) Confidence 0.35 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.18 Pain Relevance 0
Further in situ hybridization studies would be informative on PR mRNA regulation by E2 and PPT in the different cell types.
Regulation (regulation) of PR
5) Confidence 0.26 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.26 Pain Relevance 0
Thus, the regulation of PR protein levels via ER?
Regulation (regulation) of PR
6) Confidence 0.26 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.07 Pain Relevance 0
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Regulation (regulation) of epithelial PR in epithelium
7) Confidence 0.26 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0
A strong decline of CO, SV and BP but no change of HR and PR occurred after pithing in rats.
Neg (no) Regulation (change) of PR
8) Confidence 0.24 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7436631 Disease Relevance 0.12 Pain Relevance 0.11
Our previous data indicate that dopaminergic regulation of PR protein occurs only in brain regions where PR expression is sexually monomorphic and estrogen-insensitive [15], [17], suggesting functional distinction of these pathways in vivo, as well.
Regulation (regulation) of PR in brain
9) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.35
-estradiol-regulated genes such as the PR, pS2, and LIV-1 in breast cancer cells, apparently through the ER-?
Regulation (regulated) of PR associated with breast cancer
10) Confidence 0.22 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.39 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Spec (examined) Regulation (effects) of progesterone receptor in pituitary
11) Confidence 0.17 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Spec (examined) Regulation (effects) of PR in pituitary
12) Confidence 0.17 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
The PR mRNA levels do not vary in the rat uterus during the estrous cycle, suggesting that the expression of PR is primarily regulated post-translationally and/or translationally [30].
Neg (not) Regulation (vary) of PR in uterus
13) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.07 Pain Relevance 0
signalling decrease the PR mRNA levels, possibly selectively in the GE since in this structure the PR protein is also down regulated after DPN treatment.
Regulation (regulated) of PR
14) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.12 Pain Relevance 0
Little knowledge exist about possible differences in PR regulation through ERalpha or ERbeta, and whether the PR subtypes are differently regulated depending on ER type bound.
Spec (whether) Regulation (regulated) of PR
15) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.06
Control sham PR animals were anaesthetized but not wrapped and allowed to move freely in their cages.
Regulation (Control) of PR associated with stress
16) Confidence 0.13 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.13 Pain Relevance 0.33
These results support the participation of the PR and the MAPK pathway in the facilitation of lordosis behavior by delta opioid receptors.
Regulation (participation) of PR associated with delta opioid receptors and lordosis
17) Confidence 0.13 Published 2006 Journal Horm Behav Section Abstract Doc Link 16289112 Disease Relevance 0.17 Pain Relevance 0.31
Dexamethasone decreased estradiol-induced uterine cytosolic and nuclear estrogen receptor concentrations (E2 R0, p less than 0.05; E2nR0, respectively), but had no effect on estradiol-induced progesterone receptor concentrations (P4R0, p greater than 0.05).
Neg (no) Regulation (effect) of progesterone receptor in uterine associated with dexamethasone
18) Confidence 0.11 Published 1990 Journal Biol. Reprod. Section Abstract Doc Link 2310819 Disease Relevance 0.49 Pain Relevance 0.28
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Regulation (affected) of progesterone receptor in reproductive organ associated with urological neuroanatomy
19) Confidence 0.10 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.44 Pain Relevance 0
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Regulation (regulation) of epithelial PR in stroma
20) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0

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