INT2261

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Context Info
Confidence 0.77
First Reported 1979
Last Reported 2010
Negated 6
Speculated 6
Reported most in Abstract
Documents 121
Total Number 130
Disease Relevance 42.78
Pain Relevance 26.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 22
pituitary 5
follicle 2
ovaries 2
neurons 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 174 100.00 Very High Very High Very High
amygdala 45 100.00 Very High Very High Very High
Endogenous opioid 26 99.80 Very High Very High Very High
narcan 131 99.78 Very High Very High Very High
Clonidine 6 99.72 Very High Very High Very High
Hippocampus 28 99.68 Very High Very High Very High
Morphine 40 99.52 Very High Very High Very High
antagonist 60 99.46 Very High Very High Very High
Fibrositis 1 99.28 Very High Very High Very High
anesthesia 28 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 29 100.00 Very High Very High Very High
Growth Problems 3 100.00 Very High Very High Very High
Disease 896 99.92 Very High Very High Very High
Hyperandrogenism 17 99.92 Very High Very High Very High
Endometriosis (extended) 190 99.76 Very High Very High Very High
Targeted Disruption 137 99.64 Very High Very High Very High
Reprotox - General 2 21 99.40 Very High Very High Very High
Fibromyalgia 10 99.28 Very High Very High Very High
Ovarian Cancer 26 98.96 Very High Very High Very High
Adenocarcinoma 8 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of LH were higher in LD than in SD, indicating that levels of LH were sensitive to photoperiod treatment even with a controlled level of estradiol negative feedback.
Gene_expression (Levels) of LH
1) Confidence 0.77 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 20357020 Disease Relevance 0 Pain Relevance 0.14
Levels of LH were significantly higher in the NR line than in the R line, indicating genetic variation for levels of LH.
Gene_expression (Levels) of LH
2) Confidence 0.77 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 20357020 Disease Relevance 0 Pain Relevance 0.15
In this study, we show that orexin neurons, and not nearby LH neurons expressing melanin-concentrating hormone (MCH), have mu-opioid receptors and respond to chronic morphine administration and opiate antagonist-precipitated morphine withdrawal. cAMP response element-mediated transcription is induced in a subset of orexin cells, but not MCH cells, after exposure to chronic morphine or induction of withdrawal.
Gene_expression (expressing) of LH in neurons associated with antagonist, mu opioid receptor, opiate, withdrawal and morphine
3) Confidence 0.76 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12716916 Disease Relevance 0.25 Pain Relevance 1.00
These data suggest that endogenous opioids tonically suppress frequency- and amplitude-dependent neuromodulation of LH production, probably through hypothalamic mechanisms that impinge upon gonadotropin-releasing hormone-secreting peptidergic neurons.
Gene_expression (production) of LH in peptidergic neurons associated with endogenous opioid
4) Confidence 0.74 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7061693 Disease Relevance 0 Pain Relevance 0.31
LH overexpressers show elevated rather than diminished levels of
Gene_expression (overexpressers) of LH
5) Confidence 0.69 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.21 Pain Relevance 0.06
levels of gonadotropins such as LH.
Gene_expression (levels) of LH
6) Confidence 0.69 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.00 Pain Relevance 0.06
modulating LH expression and biosynthesis the longer that HRT is
Gene_expression (expression) of LH
7) Confidence 0.69 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.02 Pain Relevance 0
altered in the LH overexpressing mice, we also measured Y-maze
Gene_expression (overexpressing) of LH
8) Confidence 0.69 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.52 Pain Relevance 0.04
Alternatively, release of endogenous opioids in association with increasing feed intake or other lactational hormone responses may provide neural or pituitary inhibition of the pulsatile LH production that is requisite for ovarian follicular development.
Gene_expression (production) of LH in pituitary associated with endogenous opioid
9) Confidence 0.67 Published 1989 Journal J. Dairy Sci. Section Abstract Doc Link 2654227 Disease Relevance 0.08 Pain Relevance 0.10
Levels of LH were significantly higher in the NR line than in the R line, indicating genetic variation for levels of LH.
Gene_expression (levels) of LH
10) Confidence 0.67 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 20357020 Disease Relevance 0 Pain Relevance 0.14
Levels of LH were higher in LD than in SD, indicating that levels of LH were sensitive to photoperiod treatment even with a controlled level of estradiol negative feedback.
Gene_expression (levels) of LH
11) Confidence 0.67 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 20357020 Disease Relevance 0 Pain Relevance 0.14
We assayed levels of LH to test for genetic variation between lines that could contribute to variation in reproductive status in SD.
Gene_expression (levels) of LH
12) Confidence 0.67 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 20357020 Disease Relevance 0 Pain Relevance 0.12
To investigate whether changes in opioid tone play a role in the age-associated changes in LH release in men, the influence of an antiopioid, naltrexone, on plasma LH levels and LH pulses was studied in a group of young and elderly normal men.
Gene_expression (levels) of LH in plasma associated with opioid
13) Confidence 0.65 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2909555 Disease Relevance 0.07 Pain Relevance 0.10
Naloxone induced a significant (P less than 0.01) decrease in LH concentrations in females 10 to 60 min after injection (saline: 2.3 +/- 0.2 ng/ml plasma (SEM); 0.5 mg naloxone/kg: 1.0 +/- 0.2 ng/ml plasma and 2 mg naloxone/kg 1.2 +/- 0.4 ng/ml plasma).
Gene_expression (concentrations) of LH in plasma associated with narcan
14) Confidence 0.64 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.07 Pain Relevance 0.55
In males low doses of naloxone reduced plasma LH levels 10 to 40 min after injection (saline: 2.0 +/- 0.3 ng/ml plasma and 0.5 ng naloxone/kg: 1.1 +/- 0.3 ng/ml), whereas a decrease in plasma LH levels occurred 80 to 140 min after injection of high doses of naloxone (saline: 2.1 +/- 0.2 ng/ml and 2 mg naloxone/kg: 1.0 +/- 0.2 ng/ml).
Gene_expression (levels) of LH in plasma associated with narcan
15) Confidence 0.64 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.06 Pain Relevance 0.57
overexpresses LH [116–118] and have found that these
Gene_expression (overexpresses) of LH
16) Confidence 0.60 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.60 Pain Relevance 0.05
The acidic LH may represent the LH species newly synthesized and not well processed.
Neg (not) Gene_expression (synthesized) of LH
17) Confidence 0.60 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.04
Notably, one powerful endogenous mitogen, luteinizing hormone

(LH), a gonadotropin most often associated with reproduction, is

Gene_expression (powerful) of LH
18) Confidence 0.60 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.13 Pain Relevance 0.03
Notably, one powerful endogenous mitogen, luteinizing hormone

(LH), a gonadotropin most often associated with reproduction, is

Gene_expression (one) of LH
19) Confidence 0.60 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.13 Pain Relevance 0.03
These findings, together with data indicating that LH modulates A?
Gene_expression (modulates) of LH
20) Confidence 0.60 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 0.81 Pain Relevance 0.04

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