INT226111

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 9.76
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Anatomy Link Frequency
adipocytes 2
liver 1
cardiomyocytes 1
skeletal muscle 1
brain 1
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 86 92.24 High High
ischemia 39 91.04 High High
Endocannabinoid 70 83.12 Quite High
alcohol 144 80.16 Quite High
cytokine 25 79.68 Quite High
Inflammation 22 79.28 Quite High
Cannabinoid 66 62.80 Quite High
agonist 60 55.92 Quite High
antagonist 32 50.92 Quite High
Intracerebroventricular 2 37.16 Quite Low
Disease Link Frequency Relevance Heat
Obesity 1084 99.84 Very High Very High Very High
Stress 166 99.60 Very High Very High Very High
Aging 744 99.28 Very High Very High Very High
Impaired Glucose Tolerance 131 92.88 High High
Hypertrophy 21 92.48 High High
Cv Unclassified Under Development 39 91.04 High High
Targeted Disruption 95 85.04 High High
Metabolic Syndrome 45 83.44 Quite High
Diabetes Mellitus 99 82.12 Quite High
Alcoholic Cardiomyopathy 48 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMPK is involved in the maintenance of lipid and cholesterol homeostasis; it stimulates the ?
Gene_expression (involved) of AMPK
1) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.31 Pain Relevance 0
The heterotrimeric AMPK enzyme is widely expressed in adipose tissue, skeletal muscle, liver, heart, pancreas and brain [20], [21].
Gene_expression (expressed) of heterotrimeric AMPK enzyme in adipose tissue associated with obesity
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.27 Pain Relevance 0.09
AMPK is composed of 3 subunits (?
Gene_expression (composed) of AMPK
3) Confidence 0.39 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.24 Pain Relevance 0.05
Neither acute ethanol treatment nor ADH affected the expression of AMPK and ACC.
Gene_expression (expression) of AMPK
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.06 Pain Relevance 0.03
To explore if the AMPK signaling cascade was involved in ADH and/or ethanol-induced cardiac contractile response, AMPK, its downstream signaling molecule ACC and the AMPK activating signal LKB1 were examined.
Gene_expression (explore) of AMPK
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0.03
To monitor the change in the AMPK degrading phosphatase, expression of protein phosphatase 2A (PP2A) and protein phosphatase 2C?
Gene_expression (expression) of AMPK degrading phosphatase
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.58 Pain Relevance 0.07
To explore if the AMPK signaling cascade was involved in ADH and/or ethanol-induced cardiac contractile response, AMPK, its downstream signaling molecule ACC and the AMPK activating signal LKB1 were examined.
Gene_expression (explore) of AMPK
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0.03
Although long-term ethanol exposure is known to inhibit Glut4 expression via an AMPK-dependent pathway in adipocytes [29], our current data were unable to address the intimate interplay among AMPK signaling, insulin sensitivity, myocardial and intracellular Ca2+ derangement following acute ethanol exposure.
Gene_expression (derangement) of AMPK in adipocytes associated with obesity
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.22 Pain Relevance 0
Although long-term ethanol exposure is known to inhibit Glut4 expression via an AMPK-dependent pathway in adipocytes [29], our current data were unable to address the intimate interplay among AMPK signaling, insulin sensitivity, myocardial and intracellular Ca2+ derangement following acute ethanol exposure.
Gene_expression (expression) of AMPK-dependent in adipocytes associated with obesity
9) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.15 Pain Relevance 0
The heterotrimeric AMPK enzyme is widely expressed in adipose tissue, skeletal muscle, liver, heart, pancreas and brain [20], [21].
Gene_expression (expressed) of heterotrimeric AMPK enzyme in brain associated with obesity
10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.27 Pain Relevance 0.09
The heterotrimeric AMPK enzyme is widely expressed in adipose tissue, skeletal muscle, liver, heart, pancreas and brain [20], [21].
Gene_expression (expressed) of heterotrimeric AMPK enzyme in heart associated with obesity
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.27 Pain Relevance 0.09
The heterotrimeric AMPK enzyme is widely expressed in adipose tissue, skeletal muscle, liver, heart, pancreas and brain [20], [21].
Gene_expression (expressed) of heterotrimeric AMPK enzyme in pancreas associated with obesity
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.27 Pain Relevance 0.09
The heterotrimeric AMPK enzyme is widely expressed in adipose tissue, skeletal muscle, liver, heart, pancreas and brain [20], [21].
Gene_expression (expressed) of heterotrimeric AMPK enzyme in liver associated with obesity
13) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.27 Pain Relevance 0.09
The heterotrimeric AMPK enzyme is widely expressed in adipose tissue, skeletal muscle, liver, heart, pancreas and brain [20], [21].
Gene_expression (expressed) of heterotrimeric AMPK enzyme in skeletal muscle associated with obesity
14) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.27 Pain Relevance 0.09
AMPK was immunoprecipitated with an equal mixture of ?
Gene_expression (immunoprecipitated) of AMPK
15) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.06 Pain Relevance 0.07
Both THC and ghrelin significantly increased AMPK activity in the hypothalamus of WT mice (THC: 197±40% of control, ghrelin: 143.2±11% of control, Kruskal-Wallis test: n?
Gene_expression (activity) of AMPK in hypothalamus
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.12
IL-6 treatment for 3 h produced the sequential phosphorylation of LKB1, AMPK, ACC, and AS160 in C2C12 cells, and phosphorylation of ACC and AS160 was prevented by compound C.
Gene_expression (produced) of AMPK
17) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.07 Pain Relevance 0.03
While obesity and age alone failed to affect AMPK and its
                   phosphorylation, the combination of the two significantly attenuated AMPK
                   phosphorylation but not total AMPK expression. 
Gene_expression (expression) of AMPK associated with obesity
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.73 Pain Relevance 0
We examined the expression of Akt, eNOS,
                   AMPK and their phosphorylation in young and aging (12-month) C57 lean and
                       ob/ob mouse cardiomyocytes. 
Spec (examined) Gene_expression (expression) of AMPK in cardiomyocytes associated with aging and obesity
19) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.94 Pain Relevance 0
In
               addition, our results revealed that neither obesity nor age significantly affected
               the total expression and phosphorylation of ERK and AMPK. 
Gene_expression (expression) of AMPK associated with obesity
20) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.92 Pain Relevance 0.08

General Comments

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