INT226115

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKAA1) signal transduction (PRKAA1) nucleus (PRKAA1)
intracellular (PRKAA1) response to stress (PRKAA1) cytoplasm (PRKAA1)
Anatomy Link Frequency
leaf 1
PRKAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 33 98.72 Very High Very High Very High
Cannabinoid receptor 1 94.80 High High
antagonist 16 92.08 High High
Endocannabinoid 35 25.00 Low Low
cva 1 21.36 Low Low
agonist 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 2 95.72 Very High Very High Very High
Diabetes Mellitus 4 87.60 High High
Targeted Disruption 3 69.92 Quite High
Hyperglycemia 1 60.96 Quite High
Cv General 3 Under Development 1 21.36 Low Low
Myocardial Infarction 1 20.40 Low Low
Increased Venous Pressure Under Development 3 19.16 Low Low
Hyperlipidemia 2 17.44 Low Low
Disorder Of Lipid Metabolism 14 5.00 Very Low Very Low Very Low
Appetite Loss 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study in rats showed that DNJ and mulberry leaf extract increased the serum adiponectin level and stimulated AMP-activated protein kinase to activate the ?
Positive_regulation (stimulated) of AMP-activated protein kinase in leaf
1) Confidence 0.15 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.38 Pain Relevance 0
Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation.
Positive_regulation (activation) of AMP-activated protein kinase associated with cannabinoid
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2258435 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

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