INT226118

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.72
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) nucleus (Prkag1)
protein complex (Prkag1) response to stress (Prkag1) cytoplasm (Ghrl)
Anatomy Link Frequency
hypothalamus 2
neuronal 1
Ghrl (Mus musculus)
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 315 99.52 Very High Very High Very High
antagonist 144 99.28 Very High Very High Very High
Cannabinoid 297 98.60 Very High Very High Very High
agonist 18 79.28 Quite High
Cannabinoid receptor 9 65.44 Quite High
Glutamate 18 47.92 Quite Low
Glutamate receptor 18 5.00 Very Low Very Low Very Low
tetrodotoxin 9 5.00 Very Low Very Low Very Low
cocaine 9 5.00 Very Low Very Low Very Low
Intracerebroventricular 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 95.72 Very High Very High Very High
Appetite Loss 54 91.24 High High
Body Weight 9 9.80 Low Low
Disseminated Intravascular Coagulation 9 5.00 Very Low Very Low Very Low
Dislocations 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ghrelin did not affect AMPK activity in CB1-KO hypothalamus, and pre-administration of the CB1 antagonist rimonabant blocked the stimulatory effect of ghrelin on AMPK activity, indicating that the ghrelin-AMPK interaction requires an intact cannabinoid signaling system in the hypothalamus.
ghrelin Regulation (effect) of AMPK in hypothalamus associated with cannabinoid and antagonist
1) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.08 Pain Relevance 0.31
Ghrelin did not affect AMPK activity in CB1-KO hypothalamus, and pre-administration of the CB1 antagonist rimonabant blocked the stimulatory effect of ghrelin on AMPK activity, indicating that the ghrelin-AMPK interaction requires an intact cannabinoid signaling system in the hypothalamus.
Ghrelin Neg (not) Regulation (affect) of AMPK in hypothalamus associated with cannabinoid and antagonist
2) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.09 Pain Relevance 0.24
Therefore, the effect of ghrelin on both AMPK and appetite is clearly dependent on an intact cannabinoid pathway.
ghrelin Regulation (effect) of AMPK associated with cannabinoid
3) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.07 Pain Relevance 0.39
These data suggest that the CB1-dependent effects of ghrelin on AMPK activity and appetite are related.
ghrelin Regulation (effects) of AMPK
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.33
Our present data demonstrate that the effect of ghrelin on hypothalamic AMPK activity is also CB1-dependent.
ghrelin Regulation (effect) of AMPK
5) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.09 Pain Relevance 0.23
These data suggest not only that CB1 is necessary for the effect of ghrelin on AMPK and appetite, but also that there may be a positive feedback between the CB1 and the endogenous 2-AG synthesis.
ghrelin Regulation (effect) of AMPK
6) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.32
Correspondingly, both the genetic lack of CB1 and the pharmacological blockade of CB1 inhibited the effect of ghrelin on AMPK activity.
ghrelin Regulation (effect) of AMPK
7) Confidence 0.04 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2258435 Disease Relevance 0.17 Pain Relevance 0.45
Ghrelin's effects on AMPK, thought to mediate its orexigenic effects, are now also definitively shown to be CB1-dependent.
Ghrelin Regulation (effects) of AMPK
8) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.09 Pain Relevance 0.15
Thus, the effect of ghrelin on hypothalamic AMPK, on neuronal activity in the PVN and ultimately on appetite, are dependent on CB1, and these data would be compatible with the existence of a ghrelin?
ghrelin Regulation (effect) of AMPK in neuronal
9) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.12 Pain Relevance 0.31

General Comments

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