INT226122

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.09
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) extracellular space (Ghrl) aging (Cnr1)
extracellular region (Ghrl) plasma membrane (Cnr1) signal transducer activity (Cnr1)
Anatomy Link Frequency
hypothalamus 2
Ghrl (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 99 100.00 Very High Very High Very High
antagonist 48 97.92 Very High Very High Very High
Endocannabinoid 105 94.48 High High
agonist 6 71.60 Quite High
Glutamate 6 29.88 Quite Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
cocaine 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 18 88.40 High High
Targeted Disruption 9 38.88 Quite Low
Body Weight 3 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, ghrelin had no effect on food intake in the CB1-KO mice (ghrelin vs. control in CB1-KO mice: 0.42±0.07 g vs. 0.41±0.1 g, P?
ghrelin Neg (no) Regulation (effect) of CB1
1) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.17
Interestingly, rimonabant administration blocked the stimulatory effect of ghrelin on 2-AG content and ghrelin had no effect on cannabinoid content of the hypothalamus in CB1-KO animals.
ghrelin Neg (no) Regulation (effect) of CB1 in hypothalamus associated with cannabinoid
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.35
Ghrelin did not affect AMPK activity in CB1-KO hypothalamus, and pre-administration of the CB1 antagonist rimonabant blocked the stimulatory effect of ghrelin on AMPK activity, indicating that the ghrelin-AMPK interaction requires an intact cannabinoid signaling system in the hypothalamus.
Ghrelin Neg (not) Regulation (affect) of CB1 in hypothalamus associated with cannabinoid and antagonist
3) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.09 Pain Relevance 0.24

General Comments

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