INT226128

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.28
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) nucleus (Prkag1)
protein complex (Prkag1) response to stress (Prkag1) cytoplasm (Ghrl)
Anatomy Link Frequency
neuronal 2
Ghrl (Mus musculus)
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 105 99.52 Very High Very High Very High
Cannabinoid 99 99.44 Very High Very High Very High
antagonist 48 92.24 High High
Glutamate 6 50.64 Quite High
Glutamate receptor 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
cocaine 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 18 91.24 High High
Targeted Disruption 9 64.56 Quite High
Body Weight 3 9.80 Low Low
Disseminated Intravascular Coagulation 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our present data demonstrate that the effect of ghrelin on hypothalamic AMPK activity is also CB1-dependent.
Positive_regulation (dependent) of ghrelin Regulation (effect) of AMPK
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.09 Pain Relevance 0.23
Thus, the effect of ghrelin on hypothalamic AMPK, on neuronal activity in the PVN and ultimately on appetite, are dependent on CB1, and these data would be compatible with the existence of a ghrelin?
Positive_regulation (dependent) of ghrelin Regulation (effect) of AMPK in neuronal
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.12 Pain Relevance 0.32
Therefore, the effect of ghrelin on both AMPK and appetite is clearly dependent on an intact cannabinoid pathway.
Positive_regulation (dependent) of ghrelin Regulation (effect) of AMPK associated with cannabinoid
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.07 Pain Relevance 0.42

General Comments

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