INT226162

Context Info Confidence 0.28 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.77 Pain Relevance 0.13

cytosol (Foxo1) nucleus (Foxo1) embryo development (Foxo1) DNA binding (Foxo1) transcription factor binding (Foxo1) cytoplasm (Foxo1)

Anatomy Link Frequency CAR 1 head 1 Foxo1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 3 68.60 Inflammation 27 68.20 antagonist 21 23.96 Bile 39 5.00 tolerance 18 5.00 agonist 10 5.00 Crohn's disease 6 5.00 Somatostatin 4 5.00 Kinase C 3 5.00 antidepressant 3 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 28 82.28 Diabetes Mellitus 38 79.52 INFLAMMATION 25 68.20 Necrosis 2 66.68 Cancer 23 66.32 Hepatocellular Cancer 2 55.04 Muscular Atrophy 4 53.36 Acidosis 6 51.04 Chronic Renal Failure 28 50.00 Frailty 19 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

FOXO1 has been shown to bind directly to the promoters of gluconeogenic genes and activate the process of glucose production [120–122].

FOXO1 Binding (bind) of

1) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.17 Pain Relevance 0

In addition to inhibiting FoxO1 activity, drug-activated SXR and CAR were also shown to inhibit HNF4?

FoxO1 Binding (activity) of in CAR

2) Confidence 0.16 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.08 Pain Relevance 0

The activation of atrogin-1, and hence the UPS, involves another mechanism: changes in activity of the fork-head transcription factors (FoxO 1, 3 and 4).

FoxO 1 Binding (activity) of in head

3) Confidence 0.03 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.51 Pain Relevance 0.13

General Comments

This test has worked.