INT226162

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo1) nucleus (Foxo1) embryo development (Foxo1)
DNA binding (Foxo1) transcription factor binding (Foxo1) cytoplasm (Foxo1)
Anatomy Link Frequency
CAR 1
head 1
Foxo1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 68.60 Quite High
Inflammation 27 68.20 Quite High
antagonist 21 23.96 Low Low
Bile 39 5.00 Very Low Very Low Very Low
tolerance 18 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 28 82.28 Quite High
Diabetes Mellitus 38 79.52 Quite High
INFLAMMATION 25 68.20 Quite High
Necrosis 2 66.68 Quite High
Cancer 23 66.32 Quite High
Hepatocellular Cancer 2 55.04 Quite High
Muscular Atrophy 4 53.36 Quite High
Acidosis 6 51.04 Quite High
Chronic Renal Failure 28 50.00 Quite Low
Frailty 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FOXO1 has been shown to bind directly to the promoters of gluconeogenic genes and activate the process of glucose production [120–122].
FOXO1 Binding (bind) of
1) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.17 Pain Relevance 0
In addition to inhibiting FoxO1 activity, drug-activated SXR and CAR were also shown to inhibit HNF4?
FoxO1 Binding (activity) of in CAR
2) Confidence 0.16 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.08 Pain Relevance 0
The activation of atrogin-1, and hence the UPS, involves another mechanism: changes in activity of the fork-head transcription factors (FoxO 1, 3 and 4).
FoxO 1 Binding (activity) of in head
3) Confidence 0.03 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.51 Pain Relevance 0.13

General Comments

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