INT226163

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo1) nucleus (Foxo1) embryo development (Foxo1)
DNA binding (Foxo1) transcription factor binding (Foxo1) cytoplasm (Foxo1)
Anatomy Link Frequency
nucleus 2
Foxo1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 11 88.24 High High
Inflammation 10 76.48 Quite High
cytokine 5 69.60 Quite High
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 10 88.24 High High
Frailty 19 84.96 Quite High
Hypertrophy 2 84.48 Quite High
INFLAMMATION 13 76.48 Quite High
Cancer 5 73.84 Quite High
Necrosis 1 73.36 Quite High
Insulin Resistance 30 67.16 Quite High
Diabetes Mellitus 11 61.60 Quite High
Chronic Renal Failure 28 50.00 Quite Low
Stress 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas previous studies showed that Akt reduced transactivation of Foxo1 through the phosphorylation of Foxo1 at Ser256 (37,38), our data demonstrated that the phosphorylation of Foxo1 at Ser256 was augmented by reduction of ROS independently of the insulin signal at Akt phosphorylation level.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Foxo1
1) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.22 Pain Relevance 0.08
Akt-P also phosphorylates the forkhead (FoxO) transcription factor, preventing it from entering the nucleus to promote expression of atrogin-1, MuRF-1, and other atrogenes, thereby blocking protein degradation.
Negative_regulation (preventing) of Phosphorylation (phosphorylates) of forkhead in nucleus
2) Confidence 0.04 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.61 Pain Relevance 0.11

General Comments

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