INT226167

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.42
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fbxo32)
Anatomy Link Frequency
muscle 2
nucleus 2
Fbxo32 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 82.80 Quite High
cytokine 11 62.20 Quite High
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 85.68 High High
INFLAMMATION 28 82.80 Quite High
Muscular Atrophy 13 76.72 Quite High
Insulin Resistance 18 75.88 Quite High
Acidosis 12 74.40 Quite High
Chronic Renal Failure 56 68.88 Quite High
Frailty 57 66.88 Quite High
Necrosis 2 60.28 Quite High
Cancer 10 59.92 Quite High
Appetite Loss 20 39.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GSNO effectively blocked MAFbx/atrogin-1 mRNA expression induced by LPS (Fig. 5A and 5B) and promoted iNos mRNA expression both with and without LPS injection (Fig. 5C and 5D).
Positive_regulation (induced) of Transcription (expression) of atrogin-1
1) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.14 Pain Relevance 0.03
However, when PI3K/Akt activities are low, the FoxOs are not phosphorylated, so they can enter the nucleus to increase the transcription of atrogin-1, resulting in an increase in muscle protein degradation [35–37].
Positive_regulation (increase) of Transcription (transcription) of atrogin-1 in muscle
2) Confidence 0.14 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.66 Pain Relevance 0.12
When these transcription factors are phosphorylated by Akt, they cannot enter the nucleus to stimulate transcription of atrogin-1.
Positive_regulation (stimulate) of Transcription (transcription) of atrogin-1 in nucleus
3) Confidence 0.12 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.63 Pain Relevance 0.13

General Comments

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