INT226171

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.85
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Trim63)
Anatomy Link Frequency
muscle 3
Trim63 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 30 97.72 Very High Very High Very High
cytokine 9 95.68 Very High Very High Very High
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 39 97.72 Very High Very High Very High
Frailty 57 94.08 High High
Necrosis 3 93.76 High High
Cancer 15 93.40 High High
Hypertrophy 6 90.16 High High
Muscular Atrophy 12 89.36 High High
Insulin Resistance 27 88.76 High High
Acidosis 18 87.04 High High
Chronic Renal Failure 84 81.52 Quite High
Diabetes Mellitus 15 55.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of Akt on the other E3 ubiquitin ligase involved in muscle proteolysis, MuRF-1, is not as clearly established, and it may be linked to inflammation, as activation of NF-?
Protein_catabolism (proteolysis) of MuRF-1 in muscle associated with inflammation
1) Confidence 0.24 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.56 Pain Relevance 0.05
The rise in muscle protein losses is associated with two catalytic processes: first, caspase-3 is activated to break down the complex structure of muscle; second, there is increased expression of the E3 ubiquitin ligases, atrogin-1 and MuRF-1, to degrade the proteins made available by caspase-3 [35–37] (Fig. 2).
Protein_catabolism (degrade) of MuRF-1 in muscle
2) Confidence 0.24 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.64 Pain Relevance 0
B), to free NF-B to enter the nucleus and promote MuRF-1 expression, and ultimately, muscle protein degradation.
Protein_catabolism (degradation) of MuRF-1 in muscle
3) Confidence 0.18 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.65 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox