INT226175

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2007
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.80
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
heart 1
thd (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 23 98.80 Very High Very High Very High
Arthritis 29 98.64 Very High Very High Very High
Multiple sclerosis 188 98.36 Very High Very High Very High
abatacept 4 98.20 Very High Very High Very High
cytokine 168 93.72 High High
chemokine 15 90.56 High High
Inflammation 123 89.76 High High
Inflammatory response 24 88.48 High High
Central nervous system 71 73.36 Quite High
anesthesia 2 52.12 Quite High
Disease Link Frequency Relevance Heat
Burns 127 99.56 Very High Very High Very High
Injury 53 99.48 Very High Very High Very High
Asthma 104 99.46 Very High Very High Very High
Rheumatoid Arthritis 23 98.80 Very High Very High Very High
Arthritis 33 98.64 Very High Very High Very High
Demyelinating Disease 184 98.36 Very High Very High Very High
Multiple Sclerosis 140 98.08 Very High Very High Very High
Inflammatory Bowel Disease 5 97.66 Very High Very High Very High
Infection 25 95.60 Very High Very High Very High
Adhesions 5 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B. tamiae DNA was found in the liver of one mouse infected with Th339 three weeks after inoculation (Table 3).
Regulation (infected) of Th339 in liver
1) Confidence 0.14 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2920874 Disease Relevance 0.93 Pain Relevance 0.04
Regulation of gene transcription Ub conjugation affects gene transcription because many transcription factors become conjugated to Ub, and transcription activators are degraded by the proteasome [16].
Regulation (Regulation) of Ub
2) Confidence 0.04 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0 Pain Relevance 0
Burn induces an increased Th-17 response in the heart at 3 hours after injury
Regulation (response) of Th-17 in heart associated with burns and injury
3) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.81 Pain Relevance 0.12
This does not preclude the possibility that other tissues express a Th-17 response later after injury.
Regulation (response) of Th-17 associated with injury
4) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.83 Pain Relevance 0.13
Regulation of TH17 differentiation by vitamin D3 is independent of IL-10
Regulation (Regulation) of TH17
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.09 Pain Relevance 0
These data suggest that enhanced IL-10 production following treatment with vitamin D3 may regulate TH17 differentiation via an autocrine effect in the EAE inductive phase.
Spec (may) Regulation (regulate) of TH17 associated with multiple sclerosis
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.30 Pain Relevance 0.06
These data strongly suggest that B7.1 and B7.2 are involved in the regulation of Th17 differentiation but do not exclude the role of additional pairs of co-stimulatory/inhibitory molecules.
Regulation (regulation) of Th17
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.45 Pain Relevance 0.09
Finally, the clinical report of the development of ulcerative colitis during CTLA4-Ig (abatacept) therapy in a patient with RA reinforces our hypothesis that costimulatory molecules may regulate human Th17 development [18].
Spec (may) Regulation (regulate) of Th17 associated with inflammatory bowel disease, rheumatoid arthritis and abatacept
8) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.87 Pain Relevance 0.15
and IL-6 have meanwhile been implicated in at least several aspects of asthma pathogenesis [93–95], the effects of other TH17 cell derived factors such as IL-17F, IL-22, and IL-26 have only been investigated fragmentarily.
Spec (investigated) Regulation (effects) of TH17 associated with asthma
9) Confidence 0.00 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.58 Pain Relevance 0.15
is also responsible for dampening down Th1 and Th17 responses within the context of autoimmune arthritis.
Regulation (responses) of Th17 associated with arthritis
10) Confidence 0.00 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.62 Pain Relevance 0.25
These results suggest a critical role for miR-326 in the regulation of Th17 differentiation and the pathogenesis of MS.
Regulation (regulation) of Th17 associated with multiple sclerosis
11) Confidence 0.00 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.31 Pain Relevance 0.41

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox