INT226178

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 8.29
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Th17 cells 2
blood 1
ventricles 1
Treg 1
thd (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 148 99.70 Very High Very High Very High
Arthritis 32 99.28 Very High Very High Very High
Inflammatory response 16 98.52 Very High Very High Very High
Inflammation 179 98.12 Very High Very High Very High
cytokine 252 96.16 Very High Very High Very High
Spinal cord 18 80.16 Quite High
rheumatoid arthritis 17 77.36 Quite High
chemokine 58 73.84 Quite High
Central nervous system 146 73.44 Quite High
Multiple sclerosis 75 70.04 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 12 99.96 Very High Very High Very High
Severe Combined Immunodeficiency 5 99.44 Very High Very High Very High
Toxicity 78 99.34 Very High Very High Very High
Arthritis 36 99.28 Very High Very High Very High
Injury 25 99.12 Very High Very High Very High
Asthma 416 99.04 Very High Very High Very High
INFLAMMATION 196 98.52 Very High Very High Very High
Hypersensitivity 98 98.36 Very High Very High Very High
Congenital Anomalies 3 98.04 Very High Very High Very High
Disease 146 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, B. tamiae Th239 and Th339 produced myocarditis in mice, with a diffuse inflammatory response associated with myocardial cell necrosis within both ventricles (Figure 1).
Gene_expression (produced) of Th339 in ventricles associated with necrosis, inflammatory response and coronary heart disease
1) Confidence 0.23 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2920874 Disease Relevance 1.21 Pain Relevance 0.09
The relationship between oral and IP doses of TTX is linear for Th. sirtalis (as well as other vertebrates; e.g., mice).
Gene_expression (sirtalis) of Th associated with tetrodotoxin
2) Confidence 0.12 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2265764 Disease Relevance 0 Pain Relevance 0.42
Comparing TTX toxicity in newts with TTX resistance in Th. sirtalis.
Gene_expression (sirtalis) of Th associated with tetrodotoxin and toxicity
3) Confidence 0.12 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2265764 Disease Relevance 0.10 Pain Relevance 1.01
There are at least a thousand E3 enzymes (Ub ligase), and each can recognize a specific protein substrate and catalyze the transfer of an activated Ub from the E2 carrier protein to the substrate protein [10, 15].
Gene_expression (transfer) of Ub
4) Confidence 0.04 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0 Pain Relevance 0
This does not preclude the possibility that other tissues express a Th-17 response later after injury.
Gene_expression (express) of Th-17 associated with injury
5) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.83 Pain Relevance 0.13
Moreover, vitamin D3 may be a “helper” in the generation of IL-10-producing cells in an inflammatory environment but the effect of IL-10 is not essential for vitamin D3's negative regulation of TH17 generation.


Gene_expression (generation) of TH17 associated with inflammation
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.17 Pain Relevance 0.05
The mechanism of suppression of TH17 generation by 1,25(OH)2D3 is independent on STAT1
Gene_expression (generation) of TH17
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.17 Pain Relevance 0.05
In an in vitro system using cells from mice, the active form of vitamin D3 (1,25-dihydroxyvitamin D3) suppresses both interleukin (IL)-17-producing T cells (TH17) and regulatory T cells (Treg) differentiation via a vitamin D receptor signal.
Gene_expression (producing) of TH17 in Treg
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944871 Disease Relevance 0.26 Pain Relevance 0
Hence it seems likely that 1,25(OH)2D3 suppresses the generation of TH1 and TH17 cells and probably induces the development of forkhead box protein 3 (Foxp3)+ Treg cells.
Gene_expression (generation) of TH17
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.25 Pain Relevance 0.09
Cell purification and in vitro generation of Th17 cells
Gene_expression (generation) of Th17 in Th17 cells
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0
Furthermore, these cells did not express the TH17-typical transcription factor ROR?
Neg (not) Gene_expression (express) of TH17
11) Confidence 0.01 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.38 Pain Relevance 0.06
We harvested draining LN cells (LNCs) from SJL mice that had been primed with PLP139–151 in IFA and cultured them with antigen under either neutral conditions (i.e., with antigen and an anti–IL-12p40–neutralizing antibody), or conditions favorable to the generation of Th17 (IL-23, IL-1?
Gene_expression (generation) of Th17
12) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.44 Pain Relevance 0.11
The question whether these cells play a role in mild-moderate asthmatics as well remains to be answered, especially since two recently published studies demonstrated the appearance of IL-17A and IL-22 producing TH17 cells in peripheral blood of asthmatic patients [85, 86].
Gene_expression (producing) of TH17 in blood associated with asthma and occupational lung diseases
13) Confidence 0.01 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.77 Pain Relevance 0.04
Collectively, these observations invite an alternative interpretation of the mechanism of action of IL-12p40 in neuroinflammation; namely, that its role is in the production of IL-23 and reinforcement of the Th17 effector cell population, rather than (or in addition to) the production of IL-12p70 and promotion of Th1 differentiation.
Gene_expression (production) of Th17
14) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.46 Pain Relevance 0.10
TH17, TH17/TH2, and TH22 Cells in Asthma Pathogenesis
Gene_expression (TH17) of TH17 associated with asthma
15) Confidence 0.00 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.17 Pain Relevance 0.24
TH17, TH17/TH2, and TH22 Cells in Asthma Pathogenesis
Gene_expression (TH17) of TH17 associated with asthma
16) Confidence 0.00 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.17 Pain Relevance 0.24
–treated mice to adoptively transfer arthritis to SCID mice demonstrates that the expansion of Th1/Th17 cells may have pathological consequences when the anti-TNF?
Gene_expression (expansion) of Th17 in Th17 cells associated with severe combined immunodeficiency and arthritis
17) Confidence 0.00 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.89 Pain Relevance 0.30

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