INT226182

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

thd (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 18 100.00 Very High Very High Very High
abatacept 2 65.80 Quite High
Inflammation 24 45.12 Quite Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 56 99.12 Very High Very High Very High
Muscular Atrophy 8 87.44 High High
Frailty 38 77.24 Quite High
Sepsis 10 65.36 Quite High
Starvation 2 63.68 Quite High
Cancer 11 63.20 Quite High
Acidosis 12 56.00 Quite High
Diabetes Mellitus 14 51.12 Quite High
INFLAMMATION 30 45.12 Quite Low
Disease 18 41.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these cases, changes in gene expression are most likely due to transcriptional regulation because we have shown that uremia or abnormal insulin responses increase the transcription of Ub and subunits of the proteasome [5, 6, 32].
Transcription (transcription) of Ub associated with chronic renal failure
1) Confidence 0.05 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 1.08 Pain Relevance 0
Regulation of gene transcription Ub conjugation affects gene transcription because many transcription factors become conjugated to Ub, and transcription activators are degraded by the proteasome [16].
Transcription (transcription) of Ub
2) Confidence 0.04 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0 Pain Relevance 0
We first examined the effect of anti-CD28 mAb on Th17 differentiation and cytokine mRNA expression.
Transcription (expression) of Th17 associated with cytokine
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0.15

General Comments

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