INT226185

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.43
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
poly 3
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 99.60 Very High Very High Very High
cytokine 5 92.72 High High
imagery 38 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 99.60 Very High Very High Very High
Cancer 254 98.90 Very High Very High Very High
Stress 12 97.66 Very High Very High Very High
Necrosis 1 96.48 Very High Very High Very High
Apoptosis 22 93.48 High High
Hyperplasia 12 88.72 High High
Frailty 19 73.68 Quite High
Hypertrophy 2 73.20 Quite High
Solid Tumor 2 69.88 Quite High
Insulin Resistance 9 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Degradation of Akt and phosphorylated Akt (P-Akt) leads to inactivation of cell survival pathways and the observed concomitant increase in levels of cleaved poly-(ADP-ribose) polymerase (cPARP) is indicative of apoptosis.
Protein_catabolism (Degradation) of Akt in poly associated with apoptosis
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.16 Pain Relevance 0
Degradation of Akt and phosphorylated Akt (P-Akt) leads to inactivation of cell survival pathways and the observed concomitant increase in levels of cleaved poly-(ADP-ribose) polymerase (cPARP) is indicative of apoptosis.
Protein_catabolism (Degradation) of Akt in poly associated with apoptosis
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.17 Pain Relevance 0
As with the in vitro experiments, PU-H71 was found to inhibit Hsp90 as indicated by the specific tumor fingerprints which showed increased Hsp70 expression, degradation of P-Akt and high levels of cPARP between 24 and 72 h.
Protein_catabolism (degradation) of P-Akt associated with cancer
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.53 Pain Relevance 0
Degradation of Akt and phosphorylated Akt (P-Akt) leads to inactivation of cell survival pathways and the observed concomitant increase in levels of cleaved poly-(ADP-ribose) polymerase (cPARP) is indicative of apoptosis.
Protein_catabolism (Degradation) of P-Akt in poly associated with apoptosis
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.17 Pain Relevance 0
In protein degradation, the opposite pathway happens, but additionally, decreased Akt-P leads to increased caspase-3 activity, further promoting degradation.
Protein_catabolism (degradation) of Akt-P
5) Confidence 0.23 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.73 Pain Relevance 0.14
However the question that needs to be addressed is how diminishing Akt activation by17AAG treatment (Fig 4A) could simultaneously result in induction of stress response by sharply augmenting the Hsp70 levels (Fig 4A). 17AAG blocks the chaperoning activity of Hsp90, prompting degradation of its client protein Akt.
Protein_catabolism (degradation) of Akt associated with stress
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.10 Pain Relevance 0
and Kit at nanomolar to sub-nanomolar concentrations (Table 1).11 Recently, dasatinib was also shown to bind to other tyrosine and serine/threonine kinases, such as the TEC family kinases, BTK and TEC, the mitogen-activated protein kinases, the receptor tyrosine kinase, discoidin domain receptor 1 and the ephrin receptors.12
Protein_catabolism (protein) of kinases
7) Confidence 0.01 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.29 Pain Relevance 0
and Kit at nanomolar to sub-nanomolar concentrations (Table 1).11 Recently, dasatinib was also shown to bind to other tyrosine and serine/threonine kinases, such as the TEC family kinases, BTK and TEC, the mitogen-activated protein kinases, the receptor tyrosine kinase, discoidin domain receptor 1 and the ephrin receptors.12
Protein_catabolism (protein) of kinases
8) Confidence 0.01 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.29 Pain Relevance 0

General Comments

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