INT226195

Context Info Confidence 0.48 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.23 Pain Relevance 0.20

extracellular space (Mstn) growth (Mstn) extracellular region (Mstn) molecular_function (Mstn) cytoplasm (Mstn)

Anatomy Link Frequency kidney 2 Mstn (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 3 79.36 Inflammatory marker 1 70.40 Inflammatory mediators 2 65.40 Inflammation 10 58.28 anesthesia 2 5.00 fibrosis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Renal Disease 2 100.00 Disease 8 97.72 Appetite Loss 3 96.96 Hypertrophy 2 94.12 Frailty 19 90.44 Body Weight 6 76.00 Uremia 5 70.80 INFLAMMATION 13 70.08 Insulin Resistance 9 62.92 Chronic Renal Failure 28 62.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In females only, myostatin precursor and dimer expression was altered by both trans-generational under-nutrition and postnatal diet.

Regulation (altered) of Gene_expression (expression) of myostatin precursor

1) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.08 Pain Relevance 0

In females only, myostatin precursor and dimer expression was altered by both trans-generational under-nutrition and postnatal diet, demonstrated by the UNAD females having a lower (P < 0.05) expression than ADAD and ADUN contemporaries and the dimer expression of UNAD HF-fed females being lower (P < 0.05) than UNAD chow-fed females.

Regulation (altered) of Gene_expression (expression) of myostatin precursor

2) Confidence 0.21 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0

However, there is limited information about the influence of kidney disease on myostatin expression and function beyond changes in myostatin mRNA [66, 67].

Regulation (influence) of Gene_expression (expression) of myostatin in kidney associated with renal disease

3) Confidence 0.06 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 1.16 Pain Relevance 0.20

General Comments

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