INT226195

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mstn) growth (Mstn) extracellular region (Mstn)
molecular_function (Mstn) cytoplasm (Mstn)
Anatomy Link Frequency
kidney 2
Mstn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 79.36 Quite High
Inflammatory marker 1 70.40 Quite High
Inflammatory mediators 2 65.40 Quite High
Inflammation 10 58.28 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 2 100.00 Very High Very High Very High
Disease 8 97.72 Very High Very High Very High
Appetite Loss 3 96.96 Very High Very High Very High
Hypertrophy 2 94.12 High High
Frailty 19 90.44 High High
Body Weight 6 76.00 Quite High
Uremia 5 70.80 Quite High
INFLAMMATION 13 70.08 Quite High
Insulin Resistance 9 62.92 Quite High
Chronic Renal Failure 28 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In females only, myostatin precursor and dimer expression was altered by both trans-generational under-nutrition and postnatal diet.
Regulation (altered) of Gene_expression (expression) of myostatin precursor
1) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.08 Pain Relevance 0
In females only, myostatin precursor and dimer expression was altered by both trans-generational under-nutrition and postnatal diet, demonstrated by the UNAD females having a lower (P < 0.05) expression than ADAD and ADUN contemporaries and the dimer expression of UNAD HF-fed females being lower (P < 0.05) than UNAD chow-fed females.
Regulation (altered) of Gene_expression (expression) of myostatin precursor
2) Confidence 0.21 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
However, there is limited information about the influence of kidney disease on myostatin expression and function beyond changes in myostatin mRNA [66, 67].


Regulation (influence) of Gene_expression (expression) of myostatin in kidney associated with renal disease
3) Confidence 0.06 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 1.16 Pain Relevance 0.20

General Comments

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