INT226196

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.68
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mstn) growth (Mstn) extracellular region (Mstn)
molecular_function (Mstn) cytoplasm (Mstn)
Anatomy Link Frequency
muscle 2
skeletal muscle 2
Mstn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 96.12 Very High Very High Very High
Inflammatory marker 2 87.16 High High
Inflammatory mediators 4 82.16 Quite High
Inflammation 20 75.04 Quite High
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 4 99.60 Very High Very High Very High
Appetite Loss 6 99.16 Very High Very High Very High
Disease 16 98.36 Very High Very High Very High
Frailty 38 95.92 Very High Very High Very High
Renal Disease 4 90.56 High High
Uremia 10 87.56 High High
INFLAMMATION 26 86.84 High High
Insulin Resistance 18 79.68 Quite High
Chronic Renal Failure 56 63.44 Quite High
Acidosis 12 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of myostatin precursor in skeletal muscle of males compared to females is in agreement with studies in mice [13,14].
Positive_regulation (increased) of Gene_expression (expression) of myostatin precursor in skeletal muscle
1) Confidence 0.54 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
An increase in myostatin expression is found in several cachexia-associated disease states.
Positive_regulation (increase) of Gene_expression (expression) of myostatin associated with appetite loss and disease
2) Confidence 0.10 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 1.29 Pain Relevance 0.21
Overexpression of myostatin in muscle leads to loss of protein mass via inhibition of Akt phosphorylation with an increase in active FoxO1; this increases the expression of atrophy-related genes [63, 64].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of myostatin in muscle associated with frailty
3) Confidence 0.10 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 1.39 Pain Relevance 0.25

General Comments

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