INT2262

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 142
Total Number 151
Disease Relevance 25.47
Pain Relevance 44.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 26
pituitary 5
follicle 4
blood 2
anterior pituitary 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 179 100.00 Very High Very High Very High
Morphine 76 100.00 Very High Very High Very High
opioid receptor 23 100.00 Very High Very High Very High
narcan 331 99.98 Very High Very High Very High
Opioid 92 99.98 Very High Very High Very High
Endogenous opioid 62 99.98 Very High Very High Very High
Serotonin 33 99.98 Very High Very High Very High
anesthesia 33 99.98 Very High Very High Very High
MU agonist 5 99.88 Very High Very High Very High
dexamethasone 11 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 32 99.84 Very High Very High Very High
Stress 31 99.82 Very High Very High Very High
Hypoglycemia 14 99.82 Very High Very High Very High
Endometriosis (extended) 88 99.60 Very High Very High Very High
Dysmenorrhea 14 99.28 Very High Very High Very High
Galactorrhea 24 99.04 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 98.64 Very High Very High Very High
Headache 32 98.46 Very High Very High Very High
Hirsutism 50 98.04 Very High Very High Very High
Reprotox - General 1 53 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the IEF profiles of plasma pools I and II in intact animals of both sexes were compared, the increase and the decrease in acidic to neutral LH and alkaline LH, respectively, were consistent and significant in plasma pool II.
Negative_regulation (decrease) of LH in plasma
1) Confidence 0.59 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.11
We suggest that ovarian secretions and the suckling stimulus contribute to endogenous opioid inhibition of LH during the postpartum interval.
Negative_regulation (inhibition) of LH associated with endogenous opioid
2) Confidence 0.58 Published 1989 Journal J. Anim. Sci. Section Abstract Doc Link 2670869 Disease Relevance 0 Pain Relevance 0.29
Secondly, there may be an age-dependent effect of naloxone on LH secretion during seasonal anoestrus in the ewe, with opioids playing a part in the suppression of LH in young but not in mature animals.
Negative_regulation (suppression) of LH associated with narcan and opioid
3) Confidence 0.56 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.50
In males low doses of naloxone reduced plasma LH levels 10 to 40 min after injection (saline: 2.0 +/- 0.3 ng/ml plasma and 0.5 ng naloxone/kg: 1.1 +/- 0.3 ng/ml), whereas a decrease in plasma LH levels occurred 80 to 140 min after injection of high doses of naloxone (saline: 2.1 +/- 0.2 ng/ml and 2 mg naloxone/kg: 1.0 +/- 0.2 ng/ml).
Negative_regulation (decrease) of LH in plasma associated with narcan
4) Confidence 0.56 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.06 Pain Relevance 0.56
Reduced LH pulse amplitude, induced by naltrexone, was not associated with a reduced LH response to GnRH or with a reduction in mean LH levels.
Negative_regulation (reduction) of LH
5) Confidence 0.56 Published 1994 Journal Fertil. Steril. Section Body Doc Link 8034071 Disease Relevance 0 Pain Relevance 0
Significant sleep-associated decreases in LH pulse frequency (P less than 0.01) and mean serum LH levels (P less than 0.01) were found during the NaCl control studies.
Negative_regulation (decreases) of LH
6) Confidence 0.54 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2821052 Disease Relevance 0 Pain Relevance 0.30
When the IEF profiles of plasma pools I and II in intact animals of both sexes were compared, the increase and the decrease in acidic to neutral LH and alkaline LH, respectively, were consistent and significant in plasma pool II.
Negative_regulation (decrease) of alkaline LH in plasma
7) Confidence 0.51 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.11
The effects of narcotics on serum LH appear to be mediated via specific opioid receptors, suggesting that a naturally occurring opioid-like substance exists that normally inhibits LH.
Negative_regulation (inhibits) of LH associated with opioid receptor and opioid
8) Confidence 0.51 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247215 Disease Relevance 0 Pain Relevance 0.62
Three mechanisms could be involved: an enhancement of the degradation of testosterone; a direct inhibition of testicular steroidogenesis; or, finally, an inhibition of the hypothalamic-pituitary-luteinizing hormone (LH) axis resulting in a reduction in LH-dependent testicular steroidogenesis.
Negative_regulation (inhibition) of LH in pituitary
9) Confidence 0.51 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247215 Disease Relevance 0 Pain Relevance 0.22
In these mice, plasma LH concentrations were reduced (p < 0.05), and GH treatment increased (p < 0.01) LH secretion.
Negative_regulation (reduced) of LH in plasma
10) Confidence 0.47 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8722619 Disease Relevance 0.48 Pain Relevance 0.05
The LH species possessing pI values of 7.5-8.5 is likely to be the mature type of LH exhibiting high biological potency.
Negative_regulation (type) of LH associated with potency
11) Confidence 0.43 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.05
In a third experiment we observed that subcutaneous injections of naloxone (4 mg/kg) progressively reduced the number of self-administrations of morphine into the LH, a result which suggests that this response is dependent on an opiate receptor mechanism.
Negative_regulation (reduced) of LH associated with narcan, opiate and morphine
12) Confidence 0.43 Published 1987 Journal Brain Res. Section Abstract Doc Link 3620961 Disease Relevance 0 Pain Relevance 0.56
A significant decrease of LH b/i ratio was observed during N infusion in the normal subjects.
Negative_regulation (decrease) of LH
13) Confidence 0.42 Published 1984 Journal Pharmacol Res Commun Section Abstract Doc Link 6522443 Disease Relevance 0.13 Pain Relevance 0.22
The same occurred after naltrexone treatment, when significant decreases in both the amplitude of LH pulses (P < 0.05) and the LH response to GnRH (P < 0.05) were observed.
Negative_regulation (decreases) of LH response
14) Confidence 0.41 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0 Pain Relevance 0.25
In the luteal phase, after placebo administration, the frequency of LH pulses and mean LH levels were not modified, but both the amplitude of LH pulses (P < 0.025) and the LH response to GnRH were reduced (P < 0.02).
Negative_regulation (reduced) of LH response
15) Confidence 0.41 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0 Pain Relevance 0.29
Administration of a small dose of naloxone (0.03 mg/kg BW) commensurate with occupancy of only mu-opiate receptors slowed the stress-induced decline in LH concentrations, as did administration of the kappa-receptor antagonist MR 1452.
Negative_regulation (decline) of LH associated with stress, antagonist, narcan and opiate
16) Confidence 0.41 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.48 Pain Relevance 0.70
In males low doses of naloxone reduced plasma LH levels 10 to 40 min after injection (saline: 2.0 +/- 0.3 ng/ml plasma and 0.5 ng naloxone/kg: 1.1 +/- 0.3 ng/ml), whereas a decrease in plasma LH levels occurred 80 to 140 min after injection of high doses of naloxone (saline: 2.1 +/- 0.2 ng/ml and 2 mg naloxone/kg: 1.0 +/- 0.2 ng/ml).
Negative_regulation (reduced) of LH in plasma associated with narcan
17) Confidence 0.41 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.06 Pain Relevance 0.57
Naloxone induced a significant (P less than 0.01) decrease in LH concentrations in females 10 to 60 min after injection (saline: 2.3 +/- 0.2 ng/ml plasma (SEM); 0.5 mg naloxone/kg: 1.0 +/- 0.2 ng/ml plasma and 2 mg naloxone/kg 1.2 +/- 0.4 ng/ml plasma).
Negative_regulation (decrease) of LH in plasma associated with narcan
18) Confidence 0.41 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.07 Pain Relevance 0.55
Reduced LH pulse amplitude, induced by naltrexone, was not associated with a reduced LH response to GnRH or with a reduction in mean LH levels.
Negative_regulation (reduced) of LH
19) Confidence 0.40 Published 1994 Journal Fertil. Steril. Section Body Doc Link 8034071 Disease Relevance 0 Pain Relevance 0
Pentobarbital anesthesia delayed, but did not prevent, the EB-induced LH surge in peripubertal females, while it completely abolished the P-induced LH surge.
Negative_regulation (abolished) of LH associated with anesthesia
20) Confidence 0.40 Published 1984 Journal Endocrinology Section Abstract Doc Link 6734515 Disease Relevance 0 Pain Relevance 0.10

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