INT2262

Context Info Confidence 0.59 First Reported 1979 Last Reported 2010 Negated 1 Speculated 5 Reported most in Abstract Documents 142 Total Number 151 Disease Relevance 25.47 Pain Relevance 44.81

Anatomy Link Frequency plasma 26 pituitary 5 follicle 4 blood 2 anterior pituitary 2 Lhb (Mus musculus)

Pain Link Frequency Relevance Heat agonist 179 100.00 Morphine 76 100.00 opioid receptor 23 100.00 narcan 331 99.98 Opioid 92 99.98 Endogenous opioid 62 99.98 Serotonin 33 99.98 anesthesia 33 99.98 MU agonist 5 99.88 dexamethasone 11 99.84

Disease Link Frequency Relevance Heat Targeted Disruption 32 99.84 Stress 31 99.82 Hypoglycemia 14 99.82 Endometriosis (extended) 88 99.60 Dysmenorrhea 14 99.28 Galactorrhea 24 99.04 Attention Deficit Hyperactivity Disorder 1 98.64 Headache 32 98.46 Hirsutism 50 98.04 Reprotox - General 1 53 97.98

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When the IEF profiles of plasma pools I and II in intact animals of both sexes were compared, the increase and the decrease in acidic to neutral LH and alkaline LH, respectively, were consistent and significant in plasma pool II.

Negative_regulation (decrease) of LH in plasma

1) Confidence 0.59 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.11

We suggest that ovarian secretions and the suckling stimulus contribute to endogenous opioid inhibition of LH during the postpartum interval.

Negative_regulation (inhibition) of LH associated with endogenous opioid

2) Confidence 0.58 Published 1989 Journal J. Anim. Sci. Section Abstract Doc Link 2670869 Disease Relevance 0 Pain Relevance 0.29

Secondly, there may be an age-dependent effect of naloxone on LH secretion during seasonal anoestrus in the ewe, with opioids playing a part in the suppression of LH in young but not in mature animals.

Negative_regulation (suppression) of LH associated with narcan and opioid

3) Confidence 0.56 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.50

In males low doses of naloxone reduced plasma LH levels 10 to 40 min after injection (saline: 2.0 +/- 0.3 ng/ml plasma and 0.5 ng naloxone/kg: 1.1 +/- 0.3 ng/ml), whereas a decrease in plasma LH levels occurred 80 to 140 min after injection of high doses of naloxone (saline: 2.1 +/- 0.2 ng/ml and 2 mg naloxone/kg: 1.0 +/- 0.2 ng/ml).

Negative_regulation (decrease) of LH in plasma associated with narcan

4) Confidence 0.56 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.06 Pain Relevance 0.56

Reduced LH pulse amplitude, induced by naltrexone, was not associated with a reduced LH response to GnRH or with a reduction in mean LH levels.

Negative_regulation (reduction) of LH

5) Confidence 0.56 Published 1994 Journal Fertil. Steril. Section Body Doc Link 8034071 Disease Relevance 0 Pain Relevance 0

Significant sleep-associated decreases in LH pulse frequency (P less than 0.01) and mean serum LH levels (P less than 0.01) were found during the NaCl control studies.

Negative_regulation (decreases) of LH

6) Confidence 0.54 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2821052 Disease Relevance 0 Pain Relevance 0.30

When the IEF profiles of plasma pools I and II in intact animals of both sexes were compared, the increase and the decrease in acidic to neutral LH and alkaline LH, respectively, were consistent and significant in plasma pool II.

Negative_regulation (decrease) of alkaline LH in plasma

7) Confidence 0.51 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.11

The effects of narcotics on serum LH appear to be mediated via specific opioid receptors, suggesting that a naturally occurring opioid-like substance exists that normally inhibits LH.

Negative_regulation (inhibits) of LH associated with opioid receptor and opioid

8) Confidence 0.51 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247215 Disease Relevance 0 Pain Relevance 0.62

Three mechanisms could be involved: an enhancement of the degradation of testosterone; a direct inhibition of testicular steroidogenesis; or, finally, an inhibition of the hypothalamic-pituitary-luteinizing hormone (LH) axis resulting in a reduction in LH-dependent testicular steroidogenesis.

Negative_regulation (inhibition) of LH in pituitary

9) Confidence 0.51 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247215 Disease Relevance 0 Pain Relevance 0.22

In these mice, plasma LH concentrations were reduced (p < 0.05), and GH treatment increased (p < 0.01) LH secretion.

Negative_regulation (reduced) of LH in plasma

10) Confidence 0.47 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8722619 Disease Relevance 0.48 Pain Relevance 0.05

The LH species possessing pI values of 7.5-8.5 is likely to be the mature type of LH exhibiting high biological potency.

Negative_regulation (type) of LH associated with potency

11) Confidence 0.43 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.05

In a third experiment we observed that subcutaneous injections of naloxone (4 mg/kg) progressively reduced the number of self-administrations of morphine into the LH, a result which suggests that this response is dependent on an opiate receptor mechanism.

Negative_regulation (reduced) of LH associated with narcan, opiate and morphine

12) Confidence 0.43 Published 1987 Journal Brain Res. Section Abstract Doc Link 3620961 Disease Relevance 0 Pain Relevance 0.56

A significant decrease of LH b/i ratio was observed during N infusion in the normal subjects.

Negative_regulation (decrease) of LH

13) Confidence 0.42 Published 1984 Journal Pharmacol Res Commun Section Abstract Doc Link 6522443 Disease Relevance 0.13 Pain Relevance 0.22

The same occurred after naltrexone treatment, when significant decreases in both the amplitude of LH pulses (P < 0.05) and the LH response to GnRH (P < 0.05) were observed.

Negative_regulation (decreases) of LH response

14) Confidence 0.41 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0 Pain Relevance 0.25

In the luteal phase, after placebo administration, the frequency of LH pulses and mean LH levels were not modified, but both the amplitude of LH pulses (P < 0.025) and the LH response to GnRH were reduced (P < 0.02).

Negative_regulation (reduced) of LH response

15) Confidence 0.41 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0 Pain Relevance 0.29

Administration of a small dose of naloxone (0.03 mg/kg BW) commensurate with occupancy of only mu-opiate receptors slowed the stress-induced decline in LH concentrations, as did administration of the kappa-receptor antagonist MR 1452.

Negative_regulation (decline) of LH associated with stress, antagonist, narcan and opiate

16) Confidence 0.41 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.48 Pain Relevance 0.70

In males low doses of naloxone reduced plasma LH levels 10 to 40 min after injection (saline: 2.0 +/- 0.3 ng/ml plasma and 0.5 ng naloxone/kg: 1.1 +/- 0.3 ng/ml), whereas a decrease in plasma LH levels occurred 80 to 140 min after injection of high doses of naloxone (saline: 2.1 +/- 0.2 ng/ml and 2 mg naloxone/kg: 1.0 +/- 0.2 ng/ml).

Negative_regulation (reduced) of LH in plasma associated with narcan

17) Confidence 0.41 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.06 Pain Relevance 0.57

Naloxone induced a significant (P less than 0.01) decrease in LH concentrations in females 10 to 60 min after injection (saline: 2.3 +/- 0.2 ng/ml plasma (SEM); 0.5 mg naloxone/kg: 1.0 +/- 0.2 ng/ml plasma and 2 mg naloxone/kg 1.2 +/- 0.4 ng/ml plasma).

Negative_regulation (decrease) of LH in plasma associated with narcan

18) Confidence 0.41 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.07 Pain Relevance 0.55

Reduced LH pulse amplitude, induced by naltrexone, was not associated with a reduced LH response to GnRH or with a reduction in mean LH levels.

Negative_regulation (reduced) of LH

19) Confidence 0.40 Published 1994 Journal Fertil. Steril. Section Body Doc Link 8034071 Disease Relevance 0 Pain Relevance 0

Pentobarbital anesthesia delayed, but did not prevent, the EB-induced LH surge in peripubertal females, while it completely abolished the P-induced LH surge.

Negative_regulation (abolished) of LH associated with anesthesia

20) Confidence 0.40 Published 1984 Journal Endocrinology Section Abstract Doc Link 6734515 Disease Relevance 0 Pain Relevance 0.10

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