INT226288

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SFRP1) extracellular space (SFRP1) extracellular region (SFRP1)
proteinaceous extracellular matrix (SFRP1) plasma membrane (SFRP1) intracellular (SFRP1)
SFRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 10 5.00 Very Low Very Low Very Low
backache 9 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Radiation Pneumonitis 72 100.00 Very High Very High Very High
Apoptosis 17 99.58 Very High Very High Very High
Breast Cancer 90 99.52 Very High Very High Very High
Non-small-cell Lung Cancer 9 99.16 Very High Very High Very High
Cancer 168 96.68 Very High Very High Very High
Metastasis 7 95.40 Very High Very High Very High
Adhesions 6 92.04 High High
Fatigue 63 90.96 High High
Adenocarcinoma 4 90.00 High High
Hyperplasia 3 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly to our findings, this augmented silent period was produced from both a reduction in onset angle of the FRP and a decreased FRP cessation angle.
Negative_regulation (decreased) of FRP
1) Confidence 0.43 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.68 Pain Relevance 0
Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.
Negative_regulation (loss) of SFRP1 associated with hypoxia, cancer, apoptosis, adhesions and metastasis
2) Confidence 0.34 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.41 Pain Relevance 0
-catenin activation in breast tumors appears to involve the downregulation of Wnt inhibitors, such as SFRP, WIF or DKK, leading to constitutive activation of autocrine Wnt signaling [8].
Negative_regulation (inhibitors) of SFRP associated with breast cancer
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.59 Pain Relevance 0
-catenin activation in breast tumors appears to involve the downregulation of Wnt inhibitors, such as SFRP, WIF or DKK, leading to constitutive activation of autocrine Wnt signaling [8].
Negative_regulation (downregulation) of SFRP associated with breast cancer
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.59 Pain Relevance 0
In the case of the SFRP genes and WIF1, this downregulation often occurs through methylation-induced epigenetic silencing [9], [10], and both SFRP1 and DKK have been shown to be transcriptionally repressed by MYC, a well-established breast oncogene [11].
Negative_regulation (downregulation) of SFRP
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.63 Pain Relevance 0
In conclusion, NTCP and V10 are useful indicators of risk for development of SARP in locally advanced NSCLC patients after concurrent chemotherapy and IMRT.
Negative_regulation (development) of SARP associated with radiation pneumonitis and non-small-cell lung cancer
6) Confidence 0.17 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2883984 Disease Relevance 0.55 Pain Relevance 0

General Comments

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