INT22632

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 2.28
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDC) small molecule metabolic process (HDC) lyase activity (HDC)
cellular nitrogen compound metabolic process (HDC) cellular amino acid metabolic process (HDC)
Anatomy Link Frequency
muscle 3
gland 1
HDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 9 97.08 Very High Very High Very High
Myofascial pain syndrome 12 95.32 Very High Very High Very High
Antihistamine 3 94.56 High High
headache 3 88.08 High High
Inflammation 3 85.28 High High
Analgesic 3 84.24 Quite High
Spontaneous pain 3 83.08 Quite High
peptic ulcer disease 1 82.08 Quite High
Disease Link Frequency Relevance Heat
Duodenal Ulcer 3 98.52 Very High Very High Very High
Pain 12 97.08 Very High Very High Very High
Temporomandibular Joint Disorders 12 95.32 Very High Very High Very High
Fatigue 6 88.72 High High
Headache 3 88.08 High High
INFLAMMATION 3 85.28 High High
Syndrome 1 82.48 Quite High
Disease 1 82.08 Quite High
Ulcers 1 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of these and previous results and the known actions of histamine, we propose that the histamine newly formed following the induction of HDC activity, which is itself mediated by IL-1, may be involved in inducing pain and, possibly, stiffness in muscles in temporomandibular disorders.
Positive_regulation (induction) of HDC in muscles associated with pain and myofascial pain syndrome
1) Confidence 0.69 Published 1999 Journal J. Dent. Res. Section Abstract Doc Link 10096452 Disease Relevance 0.72 Pain Relevance 0.71
Direct electrical stimulation of the muscle markedly elevated HDC activity.
Positive_regulation (elevated) of HDC in muscle
2) Confidence 0.69 Published 1999 Journal J. Dent. Res. Section Abstract Doc Link 10096452 Disease Relevance 0.55 Pain Relevance 0.46
Intraperitoneal injection of a small amount of interleukin-1 (IL-1) (from 1 to 10 microg/kg) produced a similar elevation of HDC activity in the masseter muscle.
Positive_regulation (elevation) of HDC in muscle
3) Confidence 0.69 Published 1999 Journal J. Dent. Res. Section Abstract Doc Link 10096452 Disease Relevance 0.56 Pain Relevance 0.50
Pentagastrin induced a significant increase in histidine decarboxylase activity of the oxyntic gland mucosa with the most profound increase seen in patients with duodenal ulcer.
Positive_regulation (increase) of histidine decarboxylase in gland associated with duodenal ulcer
4) Confidence 0.45 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2311876 Disease Relevance 0.44 Pain Relevance 0.08

General Comments

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