INT226337

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.51
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL10) signal transducer activity (IL10RA) cell-cell signaling (IL10)
response to stress (IL10) extracellular space (IL10) signal transduction (IL10RA)
IL10 (Homo sapiens)
IL10RA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 100 99.16 Very High Very High Very High
Inflammation 192 92.48 High High
Inflammatory response 24 86.48 High High
COX2 9 69.64 Quite High
antagonist 34 56.44 Quite High
chemokine 23 8.36 Low Low
agonist 20 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Esophageal Disease 108 93.52 High High
INFLAMMATION 217 92.48 High High
Pneumonia 115 78.00 Quite High
Asthma 315 60.64 Quite High
Stomach Cancer 3 54.84 Quite High
Skin Cancer 4 53.20 Quite High
Toxicity 62 50.00 Quite Low
Eosinophilia 19 31.24 Quite Low
Non-small-cell Lung Cancer 24 14.84 Low Low
Cancer 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL10:rs1800872 and IL10RA:rs3135932 have been shown to decrease IL10 signaling by decreasing serum levels and altering IL10-IL10RA interactions, respectively [26], [27].
IL10 Binding (interactions) of IL10RA
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.80 Pain Relevance 0.20
IL10:rs1800872 and IL10RA:rs3135932 have been shown to decrease IL10 signaling by decreasing serum levels and altering IL10-IL10RA interactions, respectively [26], [27].
IL10 Binding (interactions) of IL10RA
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.77 Pain Relevance 0.19
IL10:rs1800872 and IL10RA:rs3135932 have been shown to decrease IL10 signaling by decreasing serum levels and altering IL10-IL10RA interactions, respectively [26], [27].
IL10 Binding (interactions) of IL10RA
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.77 Pain Relevance 0.19
IL-10 binds to IL-10R1; IL-22 binds to IL-22R1; IL-26 binds to IL-20R1; and IFN-?
IL-10 Binding (binds) of IL-10R1
4) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.17 Pain Relevance 0.26

General Comments

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