INT226340

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.84
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T-cell 4
CD4 (Homo sapiens)
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 14 99.92 Very High Very High Very High
cytokine 188 98.60 Very High Very High Very High
agonist 40 87.00 High High
Inflammation 194 82.88 Quite High
chemokine 46 76.92 Quite High
psoriasis 2 71.76 Quite High
Crohn's disease 2 71.20 Quite High
antagonist 68 65.28 Quite High
fibrosis 4 32.88 Quite Low
methotrexate 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 210 99.52 Very High Very High Very High
Infection 32 98.16 Very High Very High Very High
Asthma 630 95.32 Very High Very High Very High
Cancer 10 92.08 High High
Necrosis 4 91.60 High High
Thrombocytopenia 2 77.76 Quite High
Anaemia 2 76.92 Quite High
Psoriasis 2 71.76 Quite High
Disease 40 71.20 Quite High
Recurrence 12 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to priming CD4+ T cells for high IFN-?
CD4 Binding (priming) of IFN in T cells
1) Confidence 0.03 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.11 Pain Relevance 0.22
In fact S1P decreases CD4 T cell generation of IFN-?
CD4 Binding (generation) of IFN in T cell
2) Confidence 0.03 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.66 Pain Relevance 0.37
CD4 T-cell responses are associated with the interferon (IFN)-?
CD4 Binding (associated) of interferon in T-cell
3) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 1.04 Pain Relevance 0.13
CD4 T-cell responses are associated with the interferon (IFN)-?
CD4 Binding (associated) of IFN in T-cell
4) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 1.04 Pain Relevance 0.13

General Comments

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