INT226346

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK3) signal transduction (IL21) extracellular space (IL21)
extracellular region (IL21) cytoskeleton (JAK3) cytoplasm (JAK3)
IL21 (Homo sapiens)
JAK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 91 96.76 Very High Very High Very High
adenocard 2 60.44 Quite High
Inflammation 96 42.08 Quite Low
antagonist 34 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 315 80.52 Quite High
Targeted Disruption 20 57.92 Quite High
Apoptosis 9 54.32 Quite High
INFLAMMATION 103 42.08 Quite Low
Disease 17 41.04 Quite Low
Cancer 3 30.16 Quite Low
Skin Cancer 1 17.68 Low Low
Eosinophilia 19 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 15 5.00 Very Low Very Low Very Low
Rhinitis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-21 binding stimulates activation of Janus kinase (JAK)1/JAK3 and then preferentially activates STAT-1 and STAT-3 [263].
IL-21 Binding (binding) of Positive_regulation (stimulates) of Positive_regulation (activation) of JAK3
1) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.18

General Comments

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