INT226371

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.49
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL18, IL4) extracellular region (IL18, IL4) cytosol (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
NK cells 1
basophils 1
mast cells 1
IL18 (Homo sapiens)
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 289 97.38 Very High Very High Very High
chemokine 70 96.80 Very High Very High Very High
Inflammation 298 59.64 Quite High
antagonist 102 12.96 Low Low
agonist 60 5.00 Very Low Very Low Very Low
Inflammatory response 18 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 948 87.52 High High
Occupational Lung Diseases 45 83.32 Quite High
Eosinophilia 63 63.44 Quite High
INFLAMMATION 317 59.64 Quite High
Hypersensitivity 44 58.84 Quite High
Pulmonary Disease 6 40.48 Quite Low
Mycobacterial Infection 4 40.08 Quite Low
Sarcoidosis 3 39.52 Quite Low
Disease 70 38.24 Quite Low
Apoptosis 28 31.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 also induces IL-4 and/or IL-13 production by NK cells, mast cells and basophils [240].
IL-18 Positive_regulation (induces) of IL-4 in NK cells
1) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.83 Pain Relevance 0.15
IL-18 also induces IL-4 and/or IL-13 production by NK cells, mast cells and basophils [240].
IL-18 Positive_regulation (induces) of IL-4 in mast cells
2) Confidence 0.02 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.83 Pain Relevance 0.15
IL-18 also induces IL-4 and/or IL-13 production by NK cells, mast cells and basophils [240].
IL-18 Positive_regulation (induces) of IL-4 in basophils
3) Confidence 0.02 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.83 Pain Relevance 0.15
The cytokines that induce IgE CSR and/or IgE production in humans include: IL-4 and IL-13 (essential for CSR), TSLP (increases IL-4 and IL-13), IL-18 (increases IL-4 and IL-13 in some systems), IL-25 (increases IL-4 and IL-13) and IL-33 (increases IL-4 and IL-13).
IL-18 Positive_regulation (increases) of IL-4 associated with cytokine
4) Confidence 0.00 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.33

General Comments

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