INT226389

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.93
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rl1) extracellular space (Il1rl1) extracellular region (Il1rl1)
plasma membrane (Il1rl1) intracellular (Il1rl1)
Anatomy Link Frequency
MC/9 1
basophils 1
Il1rl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 154 99.60 Very High Very High Very High
cytokine 125 91.92 High High
tolerance 1 36.00 Quite Low
Inflammatory response 16 34.52 Quite Low
antagonist 36 5.00 Very Low Very Low Very Low
chemokine 25 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 173 99.60 Very High Very High Very High
Asthma 319 86.64 High High
Targeted Disruption 20 77.12 Quite High
Anaphylaxis 46 74.32 Quite High
Eosinophilia 19 52.16 Quite High
Eczema 4 49.08 Quite Low
Rhinitis 13 39.64 Quite Low
Pruritus 1 37.92 Quite Low
Retinoblastoma 1 27.16 Quite Low
Sprains And Strains 7 17.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, mast cells could trigger the recruitment of late-phase inflammation via IL-33-mediated recruitment of ST2-expressing basophils to the site of antigen exposure.
Localization (recruitment) of ST2 in basophils associated with inflammation
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.45 Pain Relevance 0.15
Interestingly, we also found IgE-dependent activation induced a significant decrease in the mRNA for ST2 within BMMC (Figure 3A) and MC/9 cells (Figure 3B).
Localization (decrease) of ST2 in MC/9
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0
Three distinct types of ST2 (also known as T1, Fit-1, and DER4) gene products have been cloned; a soluble secreted form (ST2), a transmembrane receptor form (ST2L), and a variant form (ST2V).
Localization (secreted) of ST2L
3) Confidence 0.16 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.15

General Comments

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