INT226390

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
macrophages 1
dendritic cells 1
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 182 84.84 Quite High
Inflammation 192 53.00 Quite High
chemokine 46 45.24 Quite Low
antagonist 68 5.00 Very Low Very Low Very Low
agonist 40 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Occupational Lung Diseases 30 91.76 High High
Organ Transplantation 2 80.92 Quite High
Asthma 630 71.12 Quite High
INFLAMMATION 206 53.00 Quite High
Apoptosis 18 32.88 Quite Low
Targeted Disruption 40 5.00 Very Low Very Low Very Low
Eosinophilia 38 5.00 Very Low Very Low Very Low
Disease 34 5.00 Very Low Very Low Very Low
Rhinitis 22 5.00 Very Low Very Low Very Low
Hypersensitivity 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of Th2 in dendritic cells
1) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.43 Pain Relevance 0.11
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of Th2 in macrophages
2) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.43 Pain Relevance 0.11

General Comments

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