INT226397

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rl1) extracellular space (Il1rl1) extracellular region (Il1rl1)
plasma membrane (Il1rl1) intracellular (Il1rl1)
Anatomy Link Frequency
lung 1
Il1rl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 125 99.80 Very High Very High Very High
Inflammation 154 77.84 Quite High
tolerance 1 43.68 Quite Low
Inflammatory response 16 11.64 Low Low
antagonist 36 5.00 Very Low Very Low Very Low
chemokine 25 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 319 83.20 Quite High
Anaphylaxis 46 82.32 Quite High
Increased Venous Pressure Under Development 4 79.12 Quite High
INFLAMMATION 173 77.84 Quite High
Targeted Disruption 20 73.68 Quite High
Anaemia 3 64.92 Quite High
Eosinophilia 19 59.84 Quite High
Eczema 4 45.64 Quite Low
Pruritus 1 34.48 Quite Low
Retinoblastoma 1 23.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This occurs in response to IgE-mediated activation but not to IL-33-driven activation and we believe that this is likely due to the lack of calcium activation from ST2, compared to Fc?
Positive_regulation (activation) of ST2
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.48 Pain Relevance 0.10
Expression of mRNA for murine IL-4, IL-5, IL-6, IL-33 and ST2 were determined using commercially available FAM-labeled Taqman primers and probes (Applied Biosystems) on cDNA derived from mRNA extracted using a Qiagen RNeasy mRNA isolation kit.
Positive_regulation (murine) of ST2
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.14 Pain Relevance 0
ST2L is preferentially expressed on Th2 cells [297] and stimulates Th2 cytokine production in the lung and functions as an important effector molecule of Th2 (but not Th1) responses [298,299].
Positive_regulation (stimulates) of ST2L in lung associated with cytokine
3) Confidence 0.12 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.42 Pain Relevance 0.15

General Comments

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