INT226402

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 60
Total Number 62
Disease Relevance 23.82
Pain Relevance 8.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il33) extracellular region (Il33) nucleus (Il33)
Anatomy Link Frequency
mast cells 33
epithelial cells 3
macrophages 2
cleavage 2
skin 2
Il33 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1125 100.00 Very High Very High Very High
Inflammation 1889 99.92 Very High Very High Very High
Inflammatory response 306 98.12 Very High Very High Very High
Inflammatory stimuli 61 97.20 Very High Very High Very High
fibrosis 62 75.68 Quite High
Antinociceptive 2 72.24 Quite High
Pain 62 71.20 Quite High
reflex sympathetic dystrophy 3 42.24 Quite Low
antagonist 97 31.52 Quite Low
chemokine 87 15.68 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2258 99.92 Very High Very High Very High
Inflammatory Bowel Disease 60 99.72 Very High Very High Very High
Anaphylaxis 1322 99.68 Very High Very High Very High
Sprains And Strains 181 99.52 Very High Very High Very High
Disease 318 99.32 Very High Very High Very High
Obesity 60 98.44 Very High Very High Very High
Conjunctiva Disease 61 98.28 Very High Very High Very High
Asthma 435 98.24 Very High Very High Very High
Respiratory Syncytial Virus 1 96.04 Very High Very High Very High
Pneumonia 7 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our quantitative data shows that the expression of IL-33 by mast cells occurs in response to IgE-mediated activation but not to IL-33 concentrations that potently activated production of other cytokines, suggesting that autocrine amplification is unlikey.
Gene_expression (expression) of IL-33 in mast cells associated with cytokine
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.20 Pain Relevance 0.22
Recently, IL-33 was suggested to be produced by macrophages [27].
Gene_expression (produced) of IL-33 in macrophages
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.28 Pain Relevance 0.16
The expression of IL-4, IL-5, IL-6 and IL-33 were induced in BMMC (Figure 2A) after either stimulation.
Gene_expression (expression) of IL-33
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.09
Therefore, we investigated the role of calcium processes in the expression of IL-33 in mast cells.
Gene_expression (expression) of IL-33 in mast cells
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.06
Mast cells express IL-33 constitutively and upon activation in vivo
Gene_expression (express) of IL-33 in Mast cells
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.14 Pain Relevance 0
RI, and we demonstrate that calcium is both necessary and sufficient for IL-33 expression by mast cells.
Gene_expression (expression) of IL-33 in mast cells
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.51 Pain Relevance 0.10
Functionally, we show that IL-33 is expressed within the skin and is upregulated during IgE-driven anaphylaxis.
Gene_expression (expressed) of IL-33 in skin associated with anaphylaxis
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.53 Pain Relevance 0.11
Finally, we utilized intracellular staining to investigate if primary mast cells also expressed IL-33.
Spec (investigate) Gene_expression (expressed) of IL-33 in mast cells
8) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.03
We found that IL-33 protein was detectable in unstimulated cells and enhanced in IgE/DNP stimulated cells (Figure 1C).
Gene_expression (detectable) of IL-33 protein
9) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.04
This was antigen specific, since DNP-HSA stimulated expression of IL-33 in mast cells primed with DNP-specific IgE but not OVA-specific IgE while concomitantly, OVA induced expression in these cells (Figure 1B).
Gene_expression (expression) of IL-33 in mast cells
10) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.05
We show that expression of IL-33 in response to IgE-activation required calcium and that ionomycin was sufficient to induce IL-33.
Gene_expression (expression) of IL-33
11) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2914748 Disease Relevance 0.78 Pain Relevance 0.33
Our data clearly demonstrates that mast cells express IL-33 both in vivo and in vitro and that IL-33 is upregulated upon activation, indicating that mast cells may be an important source of IL-33 during inflammation, likely via its roles as a cytokine.
Gene_expression (source) of IL-33 in mast cells associated with inflammation and cytokine
12) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.57 Pain Relevance 0.33
While IL-33 is constitutively expressed in endothelial and epithelial cells, where it may function as a transcriptional regulator, cellular sources of IL-33 and its role in inflammation remain unclear.


Gene_expression (expressed) of IL-33 in epithelial cells associated with inflammation
13) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2914748 Disease Relevance 0.64 Pain Relevance 0.31
Whether IL-33 associated production and release processes are unique to mast cells or shared by other IL-33 expressing cells remains to be determined.
Gene_expression (expressing) of IL-33 in mast cells
14) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.60 Pain Relevance 0.11
Our data clearly demonstrates that mast cells express IL-33 both in vivo and in vitro and that IL-33 is upregulated upon activation, indicating that mast cells may be an important source of IL-33 during inflammation, likely via its roles as a cytokine.
Gene_expression (express) of IL-33 in mast cells associated with inflammation and cytokine
15) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.54 Pain Relevance 0.31
To test if mast cells are a source of IL-33 in vivo, we initially studied the levels of IL-33 within the skin of mast cell-deficient mice (Strain WBB6F1/J-KitW/KitW-v) or littermate controls.
Gene_expression (source) of IL-33 in mast cell associated with sprains and strains
16) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.15 Pain Relevance 0
We hypothesized that mast cells might be a source of IL-33 due to their importance in a diverse range of inflammatory responses, and particularly Th2-type immunity.
Gene_expression (source) of IL-33 in mast cells associated with inflammatory response
17) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.54 Pain Relevance 0.15
In addition, we determined whether IL-33 protein could be detected within mast cells by flow cytometry.
Gene_expression (detected) of IL-33 protein in mast cells
18) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.05
We further explored the regulation of IL-33 expression in mast cells.
Gene_expression (expression) of IL-33 in mast cells
19) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.08
Interestingly, IL-33 fails to induce its own expression and we show a requirement for calcium-mediated processes in IL-33 expression.
Gene_expression (expression) of IL-33
20) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.44 Pain Relevance 0.15

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