INT226403

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.94
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il33) extracellular region (Il33) nucleus (Il33)
Anatomy Link Frequency
mast cells 10
Il33 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 241 94.44 High High
cytokine 176 93.60 High High
Inflammatory response 31 62.12 Quite High
tolerance 1 8.00 Low Low
Inflammatory mediators 7 5.20 Low Low
antagonist 39 5.00 Very Low Very Low Very Low
chemokine 28 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 112 99.68 Very High Very High Very High
Asthma 325 97.80 Very High Very High Very High
Respiratory Syncytial Virus 1 96.60 Very High Very High Very High
Pneumonia 7 94.44 High High
Targeted Disruption 20 88.96 High High
Eosinophilia 19 81.76 Quite High
INFLAMMATION 278 81.28 Quite High
Hypersensitivity 19 69.80 Quite High
Rhinitis 16 67.24 Quite High
Occupational Lung Diseases 15 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate that deficiency in ST2 does not alter the expression of IL-33 during anaphylaxis, suggesting ST2 is regulating responses distal to the expression of IL-33 rather than acting as an autocrine enhancer of mast cell activation.
Neg (not) Regulation (alter) of Gene_expression (expression) of IL-33 in mast cell associated with anaphylaxis
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.54 Pain Relevance 0.17
Therefore, we investigated the role of calcium processes in the expression of IL-33 in mast cells.
Spec (investigated) Regulation (role) of Gene_expression (expression) of IL-33 in mast cells
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.07
We further explored the regulation of IL-33 expression in mast cells.
Regulation (regulation) of Gene_expression (expression) of IL-33 in mast cells
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.08
IL-33 expression by mast cells is dependent on calcium and not induced by IL-33
Regulation (dependent) of Gene_expression (expression) of IL-33 in mast cells
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.08
Together, these data demonstrate that the expression of IL-33 by mast cells is dependent upon calcium activation, such as occurs via IgE/Fc?
Regulation (dependent) of Gene_expression (expression) of IL-33 in mast cells
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.03
These data suggest that modulation of IL-33 expression and/or action is a potential target for new drugs for asthma.


Regulation (modulation) of Gene_expression (expression) of IL-33 associated with asthma
6) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.40 Pain Relevance 0.20

General Comments

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