INT226407

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.81
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (T) DNA binding (T) cytoplasm (T)
Anatomy Link Frequency
dorsal horn 2
T (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 27 99.38 Very High Very High Very High
Dorsal horn 12 99.16 Very High Very High Very High
cytokine 91 90.88 High High
Inflammation 129 84.36 Quite High
tolerance 1 84.16 Quite High
withdrawal 17 56.96 Quite High
qutenza 30 55.56 Quite High
induced neuropathy 3 48.24 Quite Low
intrathecal 6 46.64 Quite Low
Neuropathic pain 12 44.64 Quite Low
Disease Link Frequency Relevance Heat
Pain 33 99.38 Very High Very High Very High
Nociception 39 95.32 Very High Very High Very High
Hypersensitivity 51 86.72 High High
INFLAMMATION 139 84.36 Quite High
Eosinophilia 19 76.20 Quite High
Sprains And Strains 4 50.20 Quite High
Neuropathic Pain 21 47.60 Quite Low
Asthma 315 39.12 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 33.52 Quite Low
Ganglion Cysts 6 32.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the animal models of pain tested in this study, genetic depletion of trkB.T1 results in attenuation of pain.
Negative_regulation (depletion) of T1 associated with pain
1) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.53 Pain Relevance 0.34
If trkB.T1 were functioning solely as a dominant negative inhibitor of signaling in the dorsal horn, the prediction would be that deletion of trkB.T1 would result in more, not less pain.
Negative_regulation (inhibitor) of T1 in dorsal horn associated with pain and dorsal horn
2) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.64 Pain Relevance 0.40
If trkB.T1 is up-regulated in the dorsal horn following noxious stimulation, then genetic depletion of trkB.T1 [23] would be expected to mitigate nocifensive behaviors in these models.
Negative_regulation (depletion) of T1 in dorsal horn associated with dorsal horn
3) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.49 Pain Relevance 0.32
Importantly, this effect is blocked by prior treatment with the JNK inhibitor SP600125 confirming that JNK as a key effector in T1/ST2 signaling [306].
Negative_regulation (effector) of T1
4) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.15 Pain Relevance 0.12

General Comments

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