INT226414

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.16
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Ccnb1) cytoplasm (Ccnb1) mitosis (Ccnb1)
nucleus (Ccnb1) cytoskeleton (Ccnb1) cell cycle (Ccnb1)
Anatomy Link Frequency
M cell 2
Ccnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 91 91.56 High High
Inflammation 96 73.44 Quite High
antagonist 34 5.00 Very Low Very Low Very Low
positron emission tomography 24 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 13 99.64 Very High Very High Very High
Apoptosis 75 99.42 Very High Very High Very High
Retinoblastoma 1 99.04 Very High Very High Very High
Non-small-cell Lung Cancer 39 82.88 Quite High
Targeted Disruption 20 77.92 Quite High
Pruritus 1 76.08 Quite High
Lung Cancer 81 75.20 Quite High
Eczema 4 75.04 Quite High
INFLAMMATION 103 73.44 Quite High
Breast Cancer 3 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-31 is highly effective in suppressing proliferation by altering expression of cell cycle proteins, including up-regulation of p27 and down-regulation of cyclin B1, CDC2, CDK6, MCM4, and retinoblastoma.
Negative_regulation (p27) of cyclin B1 associated with retinoblastoma
1) Confidence 0.02 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.63 Pain Relevance 0.08
Lapatinib-induced inhibition of cyclins A and B1 likely slows down progression through the S and G2/M cell cycle phases, contrasting with the result showing no change in cyclin D1, a mediator of the G1 phase.
Negative_regulation (inhibition) of B1 in M cell
2) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.26 Pain Relevance 0
A possible reason for this cell cycle effect is the decrease in the protein levels of cyclins A and B1, which are regulators of S and G2/M phases, respectively.
Negative_regulation (decrease) of B1
3) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.31 Pain Relevance 0
Furthermore, lapatinib induced G1 cell cycle arrest (P < 0.0001) and apoptotic cell death (P < 0.0006) and reduced cyclin A and B1 levels, which are regulators of S and G2/M cell cycle stages, respectively.
Negative_regulation (reduced) of B1 in M cell associated with apoptosis and death
4) Confidence 0.00 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2883966 Disease Relevance 0.95 Pain Relevance 0

General Comments

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