INT226419

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.17
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
T cells 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 149 99.96 Very High Very High Very High
antagonist 74 99.16 Very High Very High Very High
Inflammatory response 20 95.08 Very High Very High Very High
aspirin 1 94.28 High High
Inflammation 149 93.04 High High
Antihistamine 1 67.00 Quite High
chemokine 28 47.56 Quite Low
agonist 20 41.36 Quite Low
withdrawal 2 38.24 Quite Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 376 95.68 Very High Very High Very High
INFLAMMATION 164 94.72 High High
Hypersensitivity 48 94.20 High High
Pneumonia 12 93.04 High High
Disease 35 92.48 High High
Eosinophilia 19 92.00 High High
Targeted Disruption 24 91.60 High High
Dermatitis 1 80.68 Quite High
Eczema 7 70.72 Quite High
Rhinitis 14 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, conditional deletion of SHIP-1 in T cells resulted in reduced Th2 responses to nitrophenylacetyl hapten conjugated to chicken ?
Negative_regulation (reduced) of Localization (responses) of Th2 in T cells
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.53 Pain Relevance 0.12
Notably, a profound reduction in Th2 polarization and the production of the effector Th2 cytokine, IL-13, was observed [6].
Negative_regulation (reduction) of Localization (polarization) of Th2 associated with cytokine
2) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.01 Pain Relevance 0.21
In vitro, the cysteinyl-leukotriene receptor antagonist pranlukast can concentration-dependently inhibit the release of Th2 cytokines (IL-3, IL-4, GM-CSF), but not of the Th1 cytokine IL-2, from mite allergen-stimulated PBMCs from asthmatic patients [37].
Negative_regulation (inhibit) of Localization (release) of Th2 associated with asthma, antagonist and cytokine
3) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.72 Pain Relevance 0.42
These observations are supported by other studies, which suggest that exposure to probiotics including Lactobacillus species, favors development of a Th1 phenotype and suppression of Th2 secreted cytokines [30].
Negative_regulation (suppression) of Localization (secreted) of Th2 associated with cytokine
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807455 Disease Relevance 0.90 Pain Relevance 0.22

General Comments

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